The Toll/NF-κB pathway in cuttlefish symbiotic accessory nidamental gland

Valérie Cornet, Joël Henry, Erwan Corre, Gildas Le Corguillé, Céline Zatylny-Gaudin

Research output: Contribution to journalArticlepeer-review


The female genital apparatus of decapod cephalopods contains a symbiotic accessory nidamental gland (ANG) that harbors bacterial symbionts. Although the ANG bacterial consortium is now well described, the impact of symbiosis on Sepia officinalis innate immunity pathways remains unknown. In silico analysis of the de novo transcriptome of ANG highlighted for the first time the existence of the NF-κB pathway in S. officinalis. Several signaling components were identified, i.e. five Toll-like receptors, eight signaling cascade features, and the immune response target gene iNOS, previously described as being involved in the initiation of bacterial symbiosis in a cephalopod gland. This work provides a first key for studying bacterial symbiosis and its impact on innate immunity in S. officinalis ANG.

Original languageEnglish
Pages (from-to)42-6
Number of pages5
JournalDevelopmental and Comparative Immunology
Issue number1
Publication statusPublished - 2015
Externally publishedYes


  • Animals
  • Genitalia
  • Immunity, Innate
  • Microbiota
  • NF-kappa B
  • Nitric Oxide Synthase Type II
  • Sepia
  • Signal Transduction
  • Symbiosis
  • Toll-Like Receptors
  • Transcriptome
  • Journal Article


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