The Tn3-family of Replicative Transposons

Emilien Nicolas, Michael Lambin, Damien Dandoy, Christine Galloy, Nathan Nguyen, Cédric Oger, Bernard Hallet

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

Abstract

The ampicillin-resistance transposon Tn3 is the archetype (“Tn3” being synonymous with “Tn1” or “Tn2”) of a large and widespread family of transposons with representatives in nearly all bacterial phyla including proteobacteria, firmicutes, and cyanobacteria. Family members are modular platforms allowing assembly, diversification, and redistribution of an ever-growing arsenal of antimicrobial resistance genes, thereby contributing along with other mobile genetic elements, to the emergence of multi-drug resistances at a rate that challenges the development of new treatments. They are also prevalent in horizontal transfer of large catabolic operons, allowing bacteria to metabolize various families of compounds, including industrial xenobiotic pollutants.
Original languageEnglish
Title of host publicationMobile DNA III
EditorsNancy Craig, Michael Chandler, M Gellert, A Lambowitz, P Rice, S Sandmeyer
PublisherAmerican Society for Microbiology
Chapter32
Pages693-726
Publication statusPublished - 2015

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Interspersed Repetitive Sequences
Ampicillin Resistance
Proteobacteria
Cyanobacteria
Multiple Drug Resistance
Xenobiotics
Operon
Bacteria
Genes
Firmicutes

Cite this

Nicolas, E., Lambin, M., Dandoy, D., Galloy, C., Nguyen, N., Oger, C., & Hallet, B. (2015). The Tn3-family of Replicative Transposons. In N. Craig, M. Chandler, M. Gellert, A. Lambowitz, P. Rice, & S. Sandmeyer (Eds.), Mobile DNA III (pp. 693-726). American Society for Microbiology.
Nicolas, Emilien ; Lambin, Michael ; Dandoy, Damien ; Galloy, Christine ; Nguyen, Nathan ; Oger, Cédric ; Hallet, Bernard. / The Tn3-family of Replicative Transposons. Mobile DNA III. editor / Nancy Craig ; Michael Chandler ; M Gellert ; A Lambowitz ; P Rice ; S Sandmeyer. American Society for Microbiology, 2015. pp. 693-726
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Nicolas, E, Lambin, M, Dandoy, D, Galloy, C, Nguyen, N, Oger, C & Hallet, B 2015, The Tn3-family of Replicative Transposons. in N Craig, M Chandler, M Gellert, A Lambowitz, P Rice & S Sandmeyer (eds), Mobile DNA III. American Society for Microbiology, pp. 693-726.

The Tn3-family of Replicative Transposons. / Nicolas, Emilien; Lambin, Michael; Dandoy, Damien; Galloy, Christine; Nguyen, Nathan; Oger, Cédric; Hallet, Bernard.

Mobile DNA III. ed. / Nancy Craig; Michael Chandler; M Gellert; A Lambowitz; P Rice; S Sandmeyer. American Society for Microbiology, 2015. p. 693-726.

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

TY - CHAP

T1 - The Tn3-family of Replicative Transposons

AU - Nicolas, Emilien

AU - Lambin, Michael

AU - Dandoy, Damien

AU - Galloy, Christine

AU - Nguyen, Nathan

AU - Oger, Cédric

AU - Hallet, Bernard

PY - 2015

Y1 - 2015

N2 - The ampicillin-resistance transposon Tn3 is the archetype (“Tn3” being synonymous with “Tn1” or “Tn2”) of a large and widespread family of transposons with representatives in nearly all bacterial phyla including proteobacteria, firmicutes, and cyanobacteria. Family members are modular platforms allowing assembly, diversification, and redistribution of an ever-growing arsenal of antimicrobial resistance genes, thereby contributing along with other mobile genetic elements, to the emergence of multi-drug resistances at a rate that challenges the development of new treatments. They are also prevalent in horizontal transfer of large catabolic operons, allowing bacteria to metabolize various families of compounds, including industrial xenobiotic pollutants.

AB - The ampicillin-resistance transposon Tn3 is the archetype (“Tn3” being synonymous with “Tn1” or “Tn2”) of a large and widespread family of transposons with representatives in nearly all bacterial phyla including proteobacteria, firmicutes, and cyanobacteria. Family members are modular platforms allowing assembly, diversification, and redistribution of an ever-growing arsenal of antimicrobial resistance genes, thereby contributing along with other mobile genetic elements, to the emergence of multi-drug resistances at a rate that challenges the development of new treatments. They are also prevalent in horizontal transfer of large catabolic operons, allowing bacteria to metabolize various families of compounds, including industrial xenobiotic pollutants.

M3 - Chapter (peer-reviewed)

SP - 693

EP - 726

BT - Mobile DNA III

A2 - Craig, Nancy

A2 - Chandler, Michael

A2 - Gellert, M

A2 - Lambowitz, A

A2 - Rice, P

A2 - Sandmeyer, S

PB - American Society for Microbiology

ER -

Nicolas E, Lambin M, Dandoy D, Galloy C, Nguyen N, Oger C et al. The Tn3-family of Replicative Transposons. In Craig N, Chandler M, Gellert M, Lambowitz A, Rice P, Sandmeyer S, editors, Mobile DNA III. American Society for Microbiology. 2015. p. 693-726