The Tn3-family of Replicative Transposons

Emilien Nicolas, Michael Lambin, Damien Dandoy, Christine Galloy, Nathan Nguyen, Cédric Oger, Bernard Hallet

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

The ampicillin-resistance transposon Tn3 is the archetype (“Tn3” being synonymous with “Tn1” or “Tn2”) of a large and widespread family of transposons with representatives in nearly all bacterial phyla including proteobacteria, firmicutes, and cyanobacteria. Family members are modular platforms allowing assembly, diversification, and redistribution of an ever-growing arsenal of antimicrobial resistance genes, thereby contributing along with other mobile genetic elements, to the emergence of multi-drug resistances at a rate that challenges the development of new treatments. They are also prevalent in horizontal transfer of large catabolic operons, allowing bacteria to metabolize various families of compounds, including industrial xenobiotic pollutants.
Original languageEnglish
Title of host publicationMobile DNA III
EditorsNancy Craig, Michael Chandler, M Gellert, A Lambowitz, P Rice, S Sandmeyer
PublisherAmerican Society for Microbiology
Chapter32
Pages693-726
Publication statusPublished - 2015

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