The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov; Y. V. Seryotkin; N. A. Tumanov; D. Paliwoda; M. Hanfland; A. V. Kurnosov; E. V. Boldyreva

doi:10.1039/C6RA17750F

The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov, Y. V. Seryotkin, N. A. Tumanov, D. Paliwoda, M. Hanfland, A. V. Kurnosov, E. V. Boldyreva

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Abstract

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

Original language	English
Pages (from-to)	92629-92637
Number of pages	9
Journal	RSC Advances
Volume	6
Issue number	95
DOIs	https://doi.org/10.1039/C6RA17750F https://doi.org/10.1039/c6ra17750f
Publication status	Published - 28 Sept 2016

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abstract = "The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.",

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AU - Seryotkin, Y. V.

AU - Tumanov, N. A.

AU - Paliwoda, D.

AU - Hanfland, M.

AU - Kurnosov, A. V.

AU - Boldyreva, E. V.

PY - 2016/9/28

Y1 - 2016/9/28

N2 - The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

AB - The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

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The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

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The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

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