The proinflammatory transcription factor NFκB: a potential target for novel therapeutical strategies

Patricia Renard; Martine Raes

doi:10.1023/A:1007652414175

The proinflammatory transcription factor NFκB: a potential target for novel therapeutical strategies

Patricia Renard, Martine Raes

Laboratory of Cellular Biochemistry and Biology

Research output: Contribution to journal › Article › peer-review

Abstract

NFκB is a ubiquitous transcription factor involved in the proinflammatory response to cytokines (such as IL-1 or TNF-α) and some particular stresses. The unraveling of the molecular mechanisms involved in its activation is quite recent, particularly in the case of IL-1-stimulated cells, but the identification of the molecules involved in this pathway opens new prospects in both pharmacological and toxicological research.

Original language	English
Pages (from-to)	341-344
Number of pages	4
Journal	Cell biology and toxicology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1023/A:1007652414175
Publication status	Published - 1999

Keywords

IκB
IKK
NFκB
Signal transduction

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abstract = "NFκB is a ubiquitous transcription factor involved in the proinflammatory response to cytokines (such as IL-1 or TNF-α) and some particular stresses. The unraveling of the molecular mechanisms involved in its activation is quite recent, particularly in the case of IL-1-stimulated cells, but the identification of the molecules involved in this pathway opens new prospects in both pharmacological and toxicological research.",

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KW - Signal transduction

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The proinflammatory transcription factor NFκB: a potential target for novel therapeutical strategies

Abstract

Keywords

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