The permeability of lysosomes to sugars. Effect of diethylstilbestrol on the osmotic activation of lysosomes induced by glucose

M. Jadot, S. Wattiaux-De Coninck, R. Wattiaux

Research output: Contribution to journalArticlepeer-review

Abstract

We have investigated the effect on the osmotic activation of rat liver lysosomes, by glucose penetration, of different substances known to inhibit the glucose transport through the plasma membrane. Diethylstilbestrol is the most efficient, particularly when purified lysosomes are used. It has no effect on osmotic activation induced by hypo-osmotic KCl. It is proposed that diethylstilbestrol reacts with specific sites involved in the glucose translocation through the lysosomal membrane. These sites could not be identified by binding experiments, presumably owing to the considerable unspecific binding of the compound to the membrane.
Original languageEnglish
Pages (from-to)981-984
Number of pages4
JournalBiochemical journal
Volume262
Issue number3
Publication statusPublished - 1 Jan 1989

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