The needle length of bacterial injectisomes is determined by a molecular ruler

Laure Journet, Céline Agrain, Petr Broz, Guy R Cornelis

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Size determination represents a fundamental requirement for multicomponent biological structures. Some pathogenic bacteria possess a weapon derived from the flagellum. Like the flagellum, this type-III secretion apparatus, called the injectisome, has a transmembrane basal body, but the external component is a needle-like structure instead of a hook and a filament. Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler.
    Original languageEnglish
    Pages (from-to)1757-60
    Number of pages4
    JournalScience (New York, N.Y.)
    Volume302
    Issue number5651
    DOIs
    Publication statusPublished - 2003

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