TY - JOUR
T1 - The needle length of bacterial injectisomes is determined by a molecular ruler
AU - Journet, Laure
AU - Agrain, Céline
AU - Broz, Petr
AU - Cornelis, Guy R
PY - 2003
Y1 - 2003
N2 - Size determination represents a fundamental requirement for multicomponent biological structures. Some pathogenic bacteria possess a weapon derived from the flagellum. Like the flagellum, this type-III secretion apparatus, called the injectisome, has a transmembrane basal body, but the external component is a needle-like structure instead of a hook and a filament. Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler.
AB - Size determination represents a fundamental requirement for multicomponent biological structures. Some pathogenic bacteria possess a weapon derived from the flagellum. Like the flagellum, this type-III secretion apparatus, called the injectisome, has a transmembrane basal body, but the external component is a needle-like structure instead of a hook and a filament. Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler.
U2 - 10.1126/science.1091422
DO - 10.1126/science.1091422
M3 - Article
C2 - 14657497
SN - 1095-9203
VL - 302
SP - 1757
EP - 1760
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
IS - 5651
ER -