The impact of instilled carbide nanoparticles on rat lungs: an in vivo perspective on acute intratracheal instillation.

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Abstract

In order to study a scenario of acute high concentration exposure via the pulmonary pathway of silicon carbide and titanium carbide nanoparticles, female Wistar rats were administered by intratracheal instillation doses of 0.5 and 5 mg/rat of each nanomaterial. Inflammatory parameters were studied: protein concentration, lactate dehydrogenase activity, total cell count and differentiated cell count (macrophages, neutrophils, oesonophils, lymphocytes). The genotoxicity potential was assessed by the formation of micronuclei from
pneumocytes type II. It was found that silicon carbide nanoparticles induce an inflammatory response and a dose dependent genotoxicity, although the genotoxicity levels are comparably lower to the inflammatory response.
Original languageEnglish
Article number012017
JournalJournal of Physics : Conference Series
Volume617
Issue number1
Early online date1 Oct 2013
DOIs
Publication statusPublished - 2015

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