The immunological monitoring of kidney and liver transplants in adult and pediatric recipients

Dinh Quang Truong, Christophe Bourdeaux, Grégoire Wieërs, Pascale Saussoy, Dominique Latinne, Raymond Reding

Research output: Contribution to journalReview articlepeer-review


Over the last half century, kidney and liver transplantation have been recognized as the treatment of choice for adult and children with end-stage renal or liver failure. Infants present a relative naïve immune system, but they are capable of mounting both cellular and humoral immune responses to the foreign antigens presented by the allograft. Immune monitoring is a way of measuring functional and molecular correlates of immune reactivity which may provide clinically useful information for identifying patients who have an increase risk of acute rejection prior to clinical symptoms or develop transplant tolerance. However, although numerous assays have been shown to predict rejection, to date no assays have been demonstrated to detect or predict transplantation tolerance. This is a summary of the published literature on promising antigen-specific and non-antigen-specific assays used for immunological monitoring in solid organ transplantation. This work also attempts to review their applicability to pediatric transplantation, specifically, pediatric kidney and liver recipients.

Original languageEnglish
Pages (from-to)18-27
Number of pages10
JournalTransplant Immunology
Issue number1-2
Publication statusPublished - Jan 2009
Externally publishedYes


  • Immunological monitoring
  • Pediatric transplantation
  • Rejection
  • Tolerance


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