The immunological monitoring of alloreactive responses in liver transplant recipients: A review

Raymond Reding, Jérémie Gras, Dinh Quang Truong, Grégoire Wieërs, Dominique Latinne

Research output: Contribution to journalReview articlepeer-review


The aim of this work is to review the current knowledge in the field of immunological monitoring of allogenic responsiveness in clinical liver transplantation. When compared to other solid-organ transplants, liver allografts are considered as immunologically privileged, and, accordingly, constitute a favorable setting to develop experimental as well as clinical strategies for minimization of immunosuppression and even induction of operational tolerance. The validation of simple, reliable, noninvasive assays exploring antidonor alloreactivity will constitute a crucial step toward implementing such approaches in the clinic. In contrast to research in rodents claiming the development of donor-specific tolerance in case of graft survivals of over 100 days without immunosuppression, it is impractical to confirm tolerance induction in this way in humans. Promising candidate assays include the detection of post-transplant immune deviation, of circulating precursors of dendritic cells subtypes, and of regulatory T cells. A conceptual framework for the development of tolerance assays in clinical liver transplantation is also proposed.

Original languageEnglish
Pages (from-to)373-383
Number of pages11
JournalLiver Transplantation
Issue number3
Publication statusPublished - Mar 2006
Externally publishedYes


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