The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Julie Vassart; Alfonso Tafur; Marisa Durante; Anne-Yseult Boucher; Laure Morimont; Jeanine Walenga; Job F. Harenberg; Jonathan Douxfils

doi:10.1016/j.thromres.2024.04.029

The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Julie Vassart
, Alfonso Tafur
, Marisa Durante
, Anne-Yseult Boucher
, Laure Morimont
, Jeanine Walenga
, Job F. Harenberg
, Jonathan Douxfils

Research output: Contribution to journal › Article › peer-review

Abstract

Highlights
- Preoperative point-of-care test to determine DOAC levels in plasma
- Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay
- A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma.
- Reference standard test significantly impacts the performance of the index test.
- Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

Original language	English
Article number	109023
Journal	Thrombosis Research
Volume	239
Issue number	July 2024
DOIs	https://doi.org/10.1016/j.thromres.2024.04.029
Publication status	Published - Jul 2024

Funding

Funders
DOASENSE GmbH
NorthShore Vascular
Cardiovascular Research Institute of Loyola University Chicago

Access to Document

10.1016/j.thromres.2024.04.029

Cite this

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title = "The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting",

abstract = "Highlights - Preoperative point-of-care test to determine DOAC levels in plasma - Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay - A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma. - Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.",

author = "Julie Vassart and Alfonso Tafur and Marisa Durante and Anne-Yseult Boucher and Laure Morimont and Jeanine Walenga and Harenberg, \{Job F.\} and Jonathan Douxfils",

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doi = "10.1016/j.thromres.2024.04.029",

language = "English",

volume = "239",

journal = "Thrombosis Research",

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publisher = "Elsevier",

number = "July 2024",

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T1 - The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

AU - Vassart, Julie

AU - Tafur, Alfonso

AU - Durante, Marisa

AU - Boucher, Anne-Yseult

AU - Morimont, Laure

AU - Walenga, Jeanine

AU - Harenberg, Job F.

AU - Douxfils, Jonathan

PY - 2024/7

Y1 - 2024/7

N2 - Highlights - Preoperative point-of-care test to determine DOAC levels in plasma - Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay - A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma. - Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

AB - Highlights - Preoperative point-of-care test to determine DOAC levels in plasma - Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay - A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma. - Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

UR - https://www.scopus.com/pages/publications/85193253944

U2 - 10.1016/j.thromres.2024.04.029

DO - 10.1016/j.thromres.2024.04.029

M3 - Article

SN - 0049-3848

VL - 239

JO - Thrombosis Research

JF - Thrombosis Research

IS - July 2024

M1 - 109023

ER -

The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Abstract

Funding

Access to Document

Other files and links

Fingerprint

Clinical Pharmacology Research Group

The BIOCOAG project : Biological assessment of the control of anticoagulation

Cite this

The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Abstract

Funding

Access to Document

Other files and links

Fingerprint

Projects

Clinical Pharmacology Research Group

The BIOCOAG project : Biological assessment of the control of anticoagulation

Cite this