The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Julie Vassart; Alfonso Tafur; Marisa Durante; Anne-Yseult Boucher; Laure Morimont; Jeanine Walenga; Job F. Harenberg; Jonathan Douxfils

doi:10.1016/j.thromres.2024.04.029

The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Julie Vassart, Alfonso Tafur, Marisa Durante, Anne-Yseult Boucher, Laure Morimont, Jeanine Walenga, Job F. Harenberg, Jonathan Douxfils

Research output: Contribution to journal › Article › peer-review

Abstract

Highlights
- Preoperative point-of-care test to determine DOAC levels in plasma
- Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay
- A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma.
- Reference standard test significantly impacts the performance of the index test.
- Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

Original language	English
Article number	109023
Journal	Thrombosis Research
Volume	239
Issue number	July 2024
DOIs	https://doi.org/10.1016/j.thromres.2024.04.029
Publication status	Published - Jul 2024

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10.1016/j.thromres.2024.04.029

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title = "The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting",

abstract = "Highlights- Preoperative point-of-care test to determine DOAC levels in plasma- Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay- A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma.- Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.",

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AU - Vassart, Julie

AU - Tafur, Alfonso

AU - Durante, Marisa

AU - Boucher, Anne-Yseult

AU - Morimont, Laure

AU - Walenga, Jeanine

AU - Harenberg, Job F.

AU - Douxfils, Jonathan

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AB - Highlights- Preoperative point-of-care test to determine DOAC levels in plasma- Comparison of the performance of a point-of-care test, UHPLC-MS/MS and a chromogenic assay- A negative DOAC Dipstick excludes residual levels of FXa inhibitors in plasma.- Reference standard test significantly impacts the performance of the index test. - Chromogenic anti-FXa assays should be validated against UHPLC-MS/MS.

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U2 - 10.1016/j.thromres.2024.04.029

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JO - Thrombosis Research

JF - Thrombosis Research

IS - July 2024

M1 - 109023

ER -

The DOAC (direct oral anticoagulant) Dipstick reliably excludes residual FXa inhibitors levels in the preoperative setting

Abstract

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