The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy

Julien Verrax, Julie Cadrobbi, Marianne Delvaux, James M. Jamison, Jacques Gilloteaux, Jack L Summers, Henryk S. Taper, Pedro Buc Calderon

Research output: Contribution to journalReview articlepeer-review

Abstract

Deficiency of alkaline and acid DNase is a hallmark in all non-necrotic cancer cells in animals and humans. These enzymes are reactivated at early stages of cancer cell death by vitamin C (acid DNase) and vitamin K3 (alkaline DNase). Moreover, the coadministration of these vitamins (in a ratio of 100:1, for C and K3, respectively) produced selective cancer cell death. Detailed morphological studies indicated that cell death is produced mainly by autoschizis, a new type of cancer cell death. Several mechanisms are involved in such a cell death induced by CK3, they included: formation of H2O2 during vitamins redox cycling, oxidative stress, DNA fragmentation, no caspase-3 activation, and cell membrane injury with progressive loss of organelle-free cytoplasm. Changes in the phosphorylation level of some critical proteins leading to inactivation of NF-κB appear as main intracellular signal transduction pathways. The increase knowledge in the mechanisms underlying cancer cells death by CK3 may ameliorate the techniques of their in vivo administration. The aim is to prepare the introduction of the association of vitamins C and K3 into human clinics as a new, non-toxic adjuvant cancer therapy.

Original languageEnglish
Pages (from-to)451-457
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume38
Issue number5
DOIs
Publication statusPublished - 1 May 2003
Externally publishedYes

Keywords

  • Autoschizis
  • Cancer
  • Oxidative stress
  • Vitamins C and K

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