Synthesis of exo-glycals and their biochemical applications

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exo-Glycals are both valuable synthetic tools and biologically relevant structures. This article reviews the novel synthetic approaches that have been reported to synthesize sugar based tri- or tetrasubstituted exocyclic enol ethers. Among those, the Julia modified olefinations as well as the transition metal catalyzed cross-couplings have been extensively developed. The synthesis of unprecedented fluorinated and sulfonylated phosphono-exo-glycals are also described. An overview of the biological applications in which exo-glycals acts as inhibitors or inactivator of relevant enzymes is finally presented.

Original languageEnglish
Pages (from-to)6512-6519
Number of pages8
Issue number45
Publication statusPublished - 8 Nov 2018


  • Carbohydrates
  • Enol ethers
  • Glycal
  • Inhibition
  • Lactones


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