Abstract
exo-Glycals are both valuable synthetic tools and biologically relevant structures. This article reviews the novel synthetic approaches that have been reported to synthesize sugar based tri- or tetrasubstituted exocyclic enol ethers. Among those, the Julia modified olefinations as well as the transition metal catalyzed cross-couplings have been extensively developed. The synthesis of unprecedented fluorinated and sulfonylated phosphono-exo-glycals are also described. An overview of the biological applications in which exo-glycals acts as inhibitors or inactivator of relevant enzymes is finally presented.
| Original language | English |
|---|---|
| Pages (from-to) | 6512-6519 |
| Number of pages | 8 |
| Journal | Tetrahedron |
| Volume | 74 |
| Issue number | 45 |
| DOIs | |
| Publication status | Published - 8 Nov 2018 |
Keywords
- Carbohydrates
- Enol ethers
- Glycal
- Inhibition
- Lactones