Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors

Research output

Research output per year 2001 2004 2005 2007 2008 2014

• 51 Citations
• 13 Conference contribution
• 7 Literature review
• 5 Poster
• 5 Article

Research output per year

Research output per year

Search results

• 2013

  coauthor on lecture: NOVEL DEVELOPMENT IN COUMARINS AS FXIIa INHIBITORS: IMPROVEMENT OF SOLUBILITY

  Bouckaert, C., Vancraeynest, C., Dolušić, E., Frédérick, R. & Pochet, L., 2013, Book of Abstracts, 27èmes Journées franco-belges de Pharmacochimie / 21èmes Conférences européennes du GP2A. Vol. OC05.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

  Open Access

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  • solubility 100%
  • lectures 100%
  • coumarins 100%
  • Coumarin Derivative 100%
  • Anticoagulant Agent 100%

  57 Downloads (Pure)

• 2008

  Design, synthesis and pharmacological evaluation of novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.

  Robert, S., Bertolla, C., Masereel, B., Dogné, J.-M. & Pochet, L., 2008, Abstract book - Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• 2007

  Microwave assisted medicinal chemistry: application to the synthesis of coumarins and cyclodextrins

  Bertolla, C., Robert, S., Pochet, L. & Masereel, B., 2007, Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• Nouveaux senseurs chimiques à base de beta-cyclodextrines comportant un motif coumarine. Synthèse, détermination structurale et étude des variations spectroscopiques

  Bertolla, C., Pochet, L. & Masereel, B., 2007, Abstract Book-21ème Journées Franco-Belges de Pharmacochimie.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• Nouvelles coumarines 3-carboxamides en tant qu'inhibiteurs de facteur XIIa

  Robert, S., Bertolla, C., Masereel, B., Dogné, J.-M. & Pochet, L., 2007, Abstract Book-21èmes Journées Franco-Belges de Pharmacochimie.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• Pharmacological evaluation of 6-chloromethyl-coumarins bearing a basic moiety in the 3-position as new anticoagulant drugs

  Robert, S., Frédérick, R., Masereel, B., Dogné, J.-M. & Pochet, L., 2007, Abstract Book-New Drugs and Drug Candidates: Recent Achievements in Medicinal Chemistry.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• 2005

  Évaluation biologique de coumarines en tant qu'inhibiteurs du complexe facteur tissulaire/facteur VIIa

  Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• Structure-based design of coumarins as potent thrombin inhibitors

  Frédérick, R., Robert, S., Charlier, C., De Ruyck, J., Masereel, B. & Pochet, L., 2005, Abstract Book-19èmes Journées Franco-Belges de Pharmacochimie.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• 2004

  Coumarins as inhibitors of serine proteases of the coagulation cascade

  Frédérick, R., Robert, S., Charlier, C., Masereel, B. & Pochet, L., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• Coumarins as serine protease inhibitors

  Pochet, L., Frédérick, R., Robert, S., Rolin, S. & Masereel, B., 2004, Abstract Book-XVIIIth International Symposium on Medicinal Chemistry.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• Étude du mode d'interaction de coumarines avec la thrombine

  Frédérick, R., Charlier, C., De Ruyck, J., Dieu, M., Robert, S., Masereel, B. & Pochet, L., 2004, Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• Évaluation biologique de dérivés coumariniques en tant qu'inhibiteurs de protéases à sérine de la cascade de la coagulation

  Robert, S., Frédérick, R., Masereel, B. & Pochet, L., 2004, Abstract Book-18èmes Journées Franco-Belges de Pharmacochimie.

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

• 2001

  Synthèse et évaluation enzymatique de nouvelles coumarines en tant qu'inhibiteurs de thrombine

  Pochet, L., Doucet, C., Pirotte, B., Frédérick, R., Delarge, J., Reboud-Ravaux, M. & Masereel, B., 2001, Abstract Book-XVèmes Journées Franco-Belges de Pharmacochimie. Universitaires, P. & Namur, D. (eds.). p. 60

  Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution