Synthesis and reactivity of highly nucleophilic pyridines

Nicolas De Rycke, Guillaume Berionni, François Couty, Herbert Mayr, Regis Goumont, Olivier R.P. David

Research output: Contribution to journalArticlepeer-review


3,4,5-Triamino-substituted pyridines are avid for electrophiles but are still willing to give them back. In these compounds three amino groups conjoin their forces into the heterocyclic nitrogen, making it a powerful Lewis base. A short and efficient synthesis is described, and the origin of its unique activity in nucleophilic organocatalysis is rationalized by kinetics and thermodynamic quantifications.

Original languageEnglish
Pages (from-to)530-533
Number of pages4
JournalOrganic Letters
Issue number3
Publication statusPublished - 4 Feb 2011
Externally publishedYes


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