Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Bernard Masereel, R.b Ouedraogo, Jean-Michel Dogné, M.H. Antoine, Pascal De Tullio, Bernard Pirotte, Lionel Pochet, Jacques Delarge, P.b Lebrun

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Abstract

Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.
Original languageUndefined/Unknown
Pages (from-to)453-456
Number of pages4
JournalEuropean Journal of Medicinal Chemistry
Volume32
Issue number5
Publication statusPublished - 1997

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