Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Bernard Masereel; R.b Ouedraogo; Jean-Michel Dogné; M.H. Antoine; Pascal De Tullio; Bernard Pirotte; Lionel Pochet; Jacques Delarge; P.b Lebrun

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Bernard Masereel, R.b Ouedraogo, Jean-Michel Dogné, M.H. Antoine, Pascal De Tullio, Bernard Pirotte, Lionel Pochet, Jacques Delarge, P.b Lebrun

Research output: Contribution to journal › Article › peer-review

24 Downloads (Pure)

Abstract

Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

Original language	Undefined/Unknown
Pages (from-to)	453-456
Number of pages	4
Journal	European Journal of Medicinal Chemistry
Volume	32
Issue number	5
Publication status	Published - 1997

Access to Document

lib_1997_eurjmedchem_32_453-456Final published version, 228 KB

Cite this

@article{933a12f674c34090a5920956f0cdf8f8,

title = "Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas",

abstract = "Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.",

author = "Bernard Masereel and R.b Ouedraogo and Jean-Michel Dogn{\'e} and M.H. Antoine and {De Tullio}, Pascal and Bernard Pirotte and Lionel Pochet and Jacques Delarge and P.b Lebrun",

year = "1997",

language = "Ind{\'e}fini/inconnu",

volume = "32",

pages = "453--456",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "5",

}

TY - JOUR

T1 - Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

AU - Masereel, Bernard

AU - Ouedraogo, R.b

AU - Dogné, Jean-Michel

AU - Antoine, M.H.

AU - De Tullio, Pascal

AU - Pirotte, Bernard

AU - Pochet, Lionel

AU - Delarge, Jacques

AU - Lebrun, P.b

PY - 1997

Y1 - 1997

N2 - Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

AB - Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

M3 - Article

SN - 0223-5234

VL - 32

SP - 453

EP - 456

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 5

ER -