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Abstract
We read with much interest the recent observational study of Nougier et al., which aimed at studying thrombin generation (TG) and fibrinolysis profiles of COVID-19 patients admitted to an intensive care unit (ICU) or to an internal medicine ward and receiving various schemes of prophylactic heparin.[1] They reported that thrombin potential remained within normal range despite heparin and that fibrinolysis was decreased in relation with increased plasminogen activator inhibitor 1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI) antigen plasma levels. Using the rotational thromboelastometry (ROTEM) delta device with EXTEM reagents and the addition of 0.625µg/mL tPA (referred to as 'TEM-tPA'), they reported decreased clot lysis in COVID-19 patients, which was more pronounced in patients who presented a thrombotic event, compared to event-free patients.
Original language | English |
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Pages (from-to) | 3121-3124 |
Number of pages | 4 |
Journal | Journal of thrombosis and haemostasis : JTH |
Volume | 18 |
Issue number | 11 |
Early online date | 2020 |
DOIs | |
Publication status | Published - 1 Nov 2020 |
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Dive into the research topics of 'Studies on hemostasis in COVID-19 deserve careful reporting of the laboratory methods, their significance and their limitations'. Together they form a unique fingerprint.Projects
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The COVILAB project : Clinical laboratory investigations related to COVID-19
Douxfils, J., Dogne, J., FAVRESSE, J., Tre-Hardy, M., Mullier, F., Haguet, H., Hardy, M., Melchionda, S., BOUVY, C., Morimont, L., Gillot, C., Djokoto, H., Alpan, L., Devel, P., Modaffari, E. & Maloteau, V.
13/03/20 → …
Project: Research