Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

Johan Wouters; Marjorie Huygens; Lionel Pochet; Bernard Pirotte; François Durant; Bernard Masereel

doi:10.1016/S0960-894X(02)00073-2

Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

Johan Wouters, Marjorie Huygens, Lionel Pochet, Bernard Pirotte, François Durant, Bernard Masereel

Unit of theoretical and structural physico-chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A pharmacophore associated to the inhibiton of α-chymotrypsin has been built based on the structural and electronic characterization of a series of coumarin derivatives. © 2002 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	1109-1112
Number of pages	4
Journal	Bioorganic and medicinal chemistry letters
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(02)00073-2
Publication status	Published - 8 Apr 2002

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10.1016/S0960-894X(02)00073-2

Cite this

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title = "Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins",

abstract = "A pharmacophore associated to the inhibiton of α-chymotrypsin has been built based on the structural and electronic characterization of a series of coumarin derivatives. {\textcopyright} 2002 Elsevier Science Ltd. All rights reserved.",

author = "Johan Wouters and Marjorie Huygens and Lionel Pochet and Bernard Pirotte and Fran{\c c}ois Durant and Bernard Masereel",

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T1 - Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

AU - Wouters, Johan

AU - Huygens, Marjorie

AU - Pochet, Lionel

AU - Pirotte, Bernard

AU - Durant, François

AU - Masereel, Bernard

PY - 2002/4/8

Y1 - 2002/4/8

N2 - A pharmacophore associated to the inhibiton of α-chymotrypsin has been built based on the structural and electronic characterization of a series of coumarin derivatives. © 2002 Elsevier Science Ltd. All rights reserved.

AB - A pharmacophore associated to the inhibiton of α-chymotrypsin has been built based on the structural and electronic characterization of a series of coumarin derivatives. © 2002 Elsevier Science Ltd. All rights reserved.

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U2 - 10.1016/S0960-894X(02)00073-2

DO - 10.1016/S0960-894X(02)00073-2

M3 - Article

C2 - 11909728

SN - 0960-894X

VL - 12

SP - 1109

EP - 1112

JO - Bioorganic and medicinal chemistry letters

JF - Bioorganic and medicinal chemistry letters

IS - 7

ER -

Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

Abstract

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STUDY OF COUMARINS WITH IMPROVED SOLUBILITY TO INHIBIT FXIIa, AN EMERGING TARGET IN THROMBOSIS RESEARCH

Physical Chemistry and characterization(PC2)

Cite this

Structural approach of the mechanism of inhibition of α-chymotrypsin by coumarins

Abstract

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Other files and links

Fingerprint

Research output

STUDY OF COUMARINS WITH IMPROVED SOLUBILITY TO INHIBIT FXIIa, AN EMERGING TARGET IN THROMBOSIS RESEARCH

Equipment

Physical Chemistry and characterization(PC2)

Cite this