Structural approach for COX-2 inhibition

Catherine Michaux, Caroline Charlier

Research output: Contribution to journalArticlepeer-review


The design of selective COX-2 inhibitors is a new approach to obtain potent anti-inflammatory drugs but with less side-effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.
Original languageEnglish
Pages (from-to)603-615
Number of pages13
JournalMini-reviews in medicinal chemistry
Publication statusPublished - 2004


  • molecular features
  • selectivity
  • COX-2 inhibitor
  • X-ray
  • drug design
  • molecular modeling
  • COX binding site


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