Abstract
The design of selective COX-2 inhibitors is a new approach to obtain potent anti-inflammatory drugs but with less side-effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.
Original language | English |
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Pages (from-to) | 603-615 |
Number of pages | 13 |
Journal | Mini-reviews in medicinal chemistry |
Volume | 4 |
Publication status | Published - 2004 |
Keywords
- molecular features
- selectivity
- COX-2 inhibitor
- X-ray
- drug design
- molecular modeling
- COX binding site