Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy

Laurence Moineaux; Caroline Charlier; Eduard Dolusic; Pierre Larrieu; Luc Pilotte; Didier Colau; Vincent Stroobant; Moreno Galleni; Bernard Masereel; Benoît Van den Eynde; Johan Wouters; Raphaël Frédérick

Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy

Laurence Moineaux, Caroline Charlier, Eduard Dolusic, Pierre Larrieu, Luc Pilotte, Didier Colau, Vincent Stroobant, Moreno Galleni, Bernard Masereel, Benoît Van den Eynde, Johan Wouters, Raphaël Frédérick

Research output: Contribution to conference › Paper

Original language	English
Pages	PC.355, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217-218
Number of pages	2
Publication status	Published - 2010
Event	EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY - Bruxelles, Belgium Duration: 5 Sep 2010 → …

Conference

Conference	EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY
Country	Belgium
City	Bruxelles
Period	5/09/10 → …

Cite this

Moineaux, L., Charlier, C., Dolusic, E., Larrieu, P., Pilotte, L., Colau, D., Stroobant, V., Galleni, M., Masereel, B., Van den Eynde, B., Wouters, J., & Frédérick, R. (2010). Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy. PC.355, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217-218. Paper presented at EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY, Bruxelles, Belgium.

Moineaux, Laurence ; Charlier, Caroline ; Dolusic, Eduard ; Larrieu, Pierre ; Pilotte, Luc ; Colau, Didier ; Stroobant, Vincent ; Galleni, Moreno ; Masereel, Bernard ; Van den Eynde, Benoît ; Wouters, Johan ; Frédérick, Raphaël. / Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy. Paper presented at EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY, Bruxelles, Belgium.2 p.

@conference{f9d2934892e440c18144ef2615f82deb,

title = "Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy",

author = "Laurence Moineaux and Caroline Charlier and Eduard Dolusic and Pierre Larrieu and Luc Pilotte and Didier Colau and Vincent Stroobant and Moreno Galleni and Bernard Masereel and {Van den Eynde}, Beno{\^i}t and Johan Wouters and Rapha{\"e}l Fr{\'e}d{\'e}rick",

year = "2010",

language = "English",

pages = "PC.355, 21st ISMC, Brussels, Belgium, September 5--9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217--218",

note = "EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY ; Conference date: 05-09-2010",

}

Moineaux, L, Charlier, C, Dolusic, E, Larrieu, P, Pilotte, L, Colau, D, Stroobant, V, Galleni, M, Masereel, B, Van den Eynde, B, Wouters, J & Frédérick, R 2010, 'Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy', Paper presented at EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY, Bruxelles, Belgium, 5/09/10 pp. PC.355, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217-218.

Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy. / Moineaux, Laurence; Charlier, Caroline; Dolusic, Eduard; Larrieu, Pierre; Pilotte, Luc; Colau, Didier; Stroobant, Vincent; Galleni, Moreno; Masereel, Bernard; Van den Eynde, Benoît; Wouters, Johan ; Frédérick, Raphaël.

2010. PC.355, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217-218 Paper presented at EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY, Bruxelles, Belgium.

Research output: Contribution to conference › Paper

TY - CONF

T1 - Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy

AU - Moineaux, Laurence

AU - Charlier, Caroline

AU - Dolusic, Eduard

AU - Larrieu, Pierre

AU - Pilotte, Luc

AU - Colau, Didier

AU - Stroobant, Vincent

AU - Galleni, Moreno

AU - Masereel, Bernard

AU - Van den Eynde, Benoît

AU - Wouters, Johan

AU - Frédérick, Raphaël

PY - 2010

Y1 - 2010

M3 - Paper

SP - PC.355, 21st ISMC, Brussels, Belgium, September 5-9, 2010, Drugs of the Future, volume 35, issue suppl. A, pp. 217-218

T2 - EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY

Y2 - 5 September 2010

ER -

Research Output

SYNTHESIS, ACTIVITY, CRYSTAL AND ELECTRONIC PROPERTIES OF ISOMERS OF CHLORO-PYRIDINYLVINYL-1H-INDOLES

Research output: Contribution to conference › Poster

coauthor on lecture: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase (TDO): discovery of an orally active TDO inhibitor.

Research output: Contribution in Book/Catalog/Report/Conference proceeding › Conference contribution

Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

Research output: Contribution to conference › Poster

Reversal of Tumoral Immune Resistance by Inhibition of Tryptophan 2,3-Dioxygenase (TDO): Design, Synthesis and Preclinical Evaluation of a Novel TDO Inhibitor.

Research output: Contribution to journal › Literature review

Conception, synthèse et étude d'inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer

Research output: Contribution to conference › Poster

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Research output: Contribution to journal › Article

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Research output: Contribution to conference › Poster

Student theses

Caractérisation enzymatique et structurale d'inhibiteurs indoliques de la tryptophane 2,3-dioxygénase. Mémoire présenté pour l'obtention du grade académique de Master en Chimie "Chimie du Vivant et des Nanomatériaux" : Finalité Spécialisée.

Student thesis: Master types › Master in Chemistry

Projects

Design, synthesis and study of enzyme modulators implicated in tryptophan metabolism and particularly in the kynurenin pathway

Project: Research

tryptophane 2,3-dioxygénase

Project: Research

Equipment

Physical Chemistry and characterization(PC2)

Facility/equipment: Technological Platform

Structural and enzymatic study of tryptophan 2.3-dioxygenase (TDO), a potential target in anticancer immunotherapy

Conference

Cite this

Related content

Research Output

SYNTHESIS, ACTIVITY, CRYSTAL AND ELECTRONIC PROPERTIES OF ISOMERS OF CHLORO-PYRIDINYLVINYL-1H-INDOLES

coauthor on lecture: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase (TDO): discovery of an orally active TDO inhibitor.

Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening

Design, synthesis and study of inhibitors of tryptophan 2,3-dioxygenase (TDO), a promising target for cancer therapy

Structural and enzymatic study of tryptophan 2,3-dioxgenase (TDO), a potential target in anticancer immunotherapy.

Tryptophan 2,3-dioxygenase (TDO) inhibitors : Identification of new scaffolds using virtual screening

Synthesis, structural, enzymatic and cellular studies of vinyl-1H-indole analogues as potential inhibitors of tryptophan 2,3-dioxygenase (TDO), an attractive target in cancer immunotherapy.

Reversal of Tumoral Immune Resistance by Inhibition of Tryptophan 2,3-Dioxygenase (TDO): Design, Synthesis and Preclinical Evaluation of a Novel TDO Inhibitor.

Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators

Synthesis, crystal and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors as Anticancer Immunomodulators

Conception, synthèse et étude d'inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

3-ALKENYL INDOLES AS TRYPTOPHAN 2,3-DIOXYGENASE INHIBITORS FOR THE ENHANCEMENT OF CANCER IMMUNOTHERAPY

Activities

Heterocycles in Bio-organic Chemistry

BOSS XIII - 13th Belgian Organic Synthesis Symposium Louvain, 15 - 20 juillet 2012

EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY

Student theses

Caractérisation enzymatique et structurale d'inhibiteurs indoliques de la tryptophane 2,3-dioxygénase. Mémoire présenté pour l'obtention du grade académique de Master en Chimie "Chimie du Vivant et des Nanomatériaux" : Finalité Spécialisée.

Projects

Design, synthesis and study of enzyme modulators implicated in tryptophan metabolism and particularly in the kynurenin pathway

tryptophane 2,3-dioxygénase

Equipment

Physical Chemistry and characterization(PC2)