TY - JOUR
T1 - Spontaneous neural activity during human slow wave sleep
AU - Dang-Vu, Thien Thanh
AU - Schabus, Manuel
AU - Desseilles, Martin
AU - Albouy, Geneviève
AU - Boly, Mélanie
AU - Darsaud, Annabelle
AU - Gais, Steffen
AU - Rauchs, Géraldine
AU - Sterpenich, Virginie
AU - Vandewalle, Gilles
AU - Carrier, Julie
AU - Moonen, Gustave
AU - Balteau, Evelyne
AU - Degueldre, Christian
AU - Luxen, André
AU - Phillips, Christophe
AU - Maquet, Pierre
PY - 2008/9/30
Y1 - 2008/9/30
N2 - Slow wave sleep (SWS) is associated with spontaneous brain oscillations that are thought to participate in sleep homeostasis and to support the processing of information related to the experiences of the previous awake period. At the cellular level, during SWS, a slow oscillation (140 microV) and delta waves (75-140 microV) during SWS in 14 non-sleep-deprived normal human volunteers. Significant increases in activity were associated with these waves in several cortical areas, including the inferior frontal, medial prefrontal, precuneus, and posterior cingulate areas. Compared with baseline activity, slow waves are associated with significant activity in the parahippocampal gyrus, cerebellum, and brainstem, whereas delta waves are related to frontal responses. No decrease in activity was observed. This study demonstrates that SWS is not a state of brain quiescence, but rather is an active state during which brain activity is consistently synchronized to the slow oscillation in specific cerebral regions. The partial overlap between the response pattern related to SWS waves and the waking default mode network is consistent with the fascinating hypothesis that brain responses synchronized by the slow oscillation restore microwake-like activity patterns that facilitate neuronal interactions.
AB - Slow wave sleep (SWS) is associated with spontaneous brain oscillations that are thought to participate in sleep homeostasis and to support the processing of information related to the experiences of the previous awake period. At the cellular level, during SWS, a slow oscillation (140 microV) and delta waves (75-140 microV) during SWS in 14 non-sleep-deprived normal human volunteers. Significant increases in activity were associated with these waves in several cortical areas, including the inferior frontal, medial prefrontal, precuneus, and posterior cingulate areas. Compared with baseline activity, slow waves are associated with significant activity in the parahippocampal gyrus, cerebellum, and brainstem, whereas delta waves are related to frontal responses. No decrease in activity was observed. This study demonstrates that SWS is not a state of brain quiescence, but rather is an active state during which brain activity is consistently synchronized to the slow oscillation in specific cerebral regions. The partial overlap between the response pattern related to SWS waves and the waking default mode network is consistent with the fascinating hypothesis that brain responses synchronized by the slow oscillation restore microwake-like activity patterns that facilitate neuronal interactions.
KW - Adolescent
KW - Adult
KW - Brain
KW - Electroencephalography
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Neurons
KW - Sleep
U2 - 10.1073/pnas.0801819105
DO - 10.1073/pnas.0801819105
M3 - Article
C2 - 18815373
SN - 0027-8424
VL - 105
SP - 15160
EP - 15165
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 39
ER -