Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation

Ludwig Dubois, Sarah Peeters, Natasja G Lieuwes, Nele Geusens, Anne Thiry, Simon Wigfield, Fabrizio Carta, Alan McIntyre, Andrea Scozzafava, Jean-Michel Dogné, Claudiu T Supuran, Adrian L Harris, Bernard Masereel

Research output: Contribution to journalArticlepeer-review

Abstract

Carbonic anhydrase (CA) IX expression is increased upon hypoxia and has been proposed as a therapeutic target since it has been associated with poor prognosis, tumor progression and pH regulation. The aim of this study was to evaluate the antitumor activity of a high CAIX-affinity indanesulfonamide (11c) combined with irradiation, compared with the general CA inhibitor acetazolamide (AZA).
Original languageEnglish
Pages (from-to)424-31
Number of pages8
JournalRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume99
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Acetazolamide
  • Animals
  • Apoptosis
  • Carbonic Anhydrase Inhibitors
  • Cell Hypoxia
  • Cell Proliferation
  • Flow Cytometry
  • HT29 Cells
  • Humans
  • Immunoblotting
  • Lactic Acid
  • Mice
  • Mice, Nude
  • Real-Time Polymerase Chain Reaction
  • Statistics, Nonparametric

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