@inbook{395e9e88c74644639ec21c40670ae45a,
title = "Small Molecule Regulators of Ferroptosis",
abstract = "Ferroptosis is a dedicated mode of cell death involving iron, reactive oxygen species and lipid peroxidation. Involved in processes such as glutathione metabolism, lysosomal iron retention or interference with lipid metabolism, leading either to activation or inhibition of ferroptosis. Given the implications of ferroptosis in diseases such as cancer, aging, Alzheimer and infectious diseases, new molecular mechanisms underlying ferroptosis and small molecules regulators that target those mechanisms have prompted a great deal of interest. Here, we discuss the current scenario of small molecules modulating ferroptosis and critically assess what is known about their mechanisms of action.",
keywords = "Fenton reaction, Iron, Lipid peroxidation, Reactive oxygen species, Small molecule",
author = "Sylvain Debieu and St{\'e}phanie Solier and Ludovic Colombeau and Antoine Versini and Fabien Sindikubwabo and Alison Forrester and Sebastian M{\"u}ller and Tatiana Ca{\~n}eque and Rapha{\"e}l Rodriguez",
note = "Funding Information: Acknowledgements The R.R. research group is funded Funding Information: The R.R. research group is funded by the European Research Council (ERC) under the European Union?s Horizon 2020 research and innovation programme (grant agreement No [647973]), the Fondation Charles Defforey-Institut de France and Ligue Contre le Cancer (Equipe Labellis?e). S.D. is funded by the Agence Nationale de la Recherche. We thank the CNRS, INSERM and Institut Curie for generous funding. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.",
year = "2021",
doi = "10.1007/978-3-030-62026-4_6",
language = "English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "81--121",
booktitle = "Advances in Experimental Medicine and Biology",
}
