Small Molecule Regulators of Ferroptosis

Sylvain Debieu, Stéphanie Solier, Ludovic Colombeau, Antoine Versini, Fabien Sindikubwabo, Alison Forrester, Sebastian Müller, Tatiana Cañeque, Raphaël Rodriguez

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter


Ferroptosis is a dedicated mode of cell death involving iron, reactive oxygen species and lipid peroxidation. Involved in processes such as glutathione metabolism, lysosomal iron retention or interference with lipid metabolism, leading either to activation or inhibition of ferroptosis. Given the implications of ferroptosis in diseases such as cancer, aging, Alzheimer and infectious diseases, new molecular mechanisms underlying ferroptosis and small molecules regulators that target those mechanisms have prompted a great deal of interest. Here, we discuss the current scenario of small molecules modulating ferroptosis and critically assess what is known about their mechanisms of action.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages41
Publication statusPublished - 2021
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Fenton reaction
  • Iron
  • Lipid peroxidation
  • Reactive oxygen species
  • Small molecule


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