Sleep sharpens sensory stimulus coding in human visual cortex after fear conditioning

Virginie Sterpenich, Camille Piguet, Martin Desseilles, Leonardo Ceravolo, Markus Gschwind, Dimitri Van De Ville, Patrik Vuilleumier, Sophie Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Efficient perceptual identification of emotionally-relevant stimuli requires optimized neural coding. Because sleep contributes to neural plasticity mechanisms, we asked whether the perceptual representation of emotionally-relevant stimuli within sensory cortices is modified after a period of sleep. We show combined effects of sleep and aversive conditioning on subsequent discrimination of face identity information, with parallel plasticity in the amygdala and visual cortex. After one night of sleep (but neither immediately nor after an equal waking interval), a fear-conditioned face was better detected when morphed with another identity. This behavioral change was accompanied by increased selectivity of the amygdala and face-responsive fusiform regions. Overnight neural changes can thus sharpen the representation of threat-related stimuli in cortical sensory areas, in order to improve detection in impoverished or ambiguous situations. These findings reveal an important role of sleep in shaping cortical selectivity to emotionally-relevant cues and thus promoting adaptive responses to new dangers.

Original languageEnglish
Pages (from-to)608-18
Number of pages11
JournalNeuroImage
Volume100
DOIs
Publication statusPublished - 15 Oct 2014

Keywords

  • Amygdala
  • Conditioning
  • Emotion
  • Functional MRI
  • Fusiform cortex
  • Memory consolidation
  • Perceptual learning
  • Sleep

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