Similarities between alanine dehydrogenase and the N-terminal part of pyridine nucleotide transhydrogenase and their possible implication in the virulence mechanism of Mycobacterium tuberculosis

D. Delforge, E. Depiereux, X. De Bolle, E. Feytmans, J. Remacle

Research output: Contribution to journalArticlepeer-review

Abstract

Recent developments in simultaneous multiple alignment methods of protein sequences allow prediction of structural similarity in related proteins. Alanine dehydrogenase and the N-terminal sequence of pyridine nucleotide transhydrogenase were compared for their sequences. High similarities of sequences were observed especially in their NAD(H)-binding sites. These similarities suggest that antibodies which recognized the alanine dehydrogenase of Mycobacterium tuberculosis can also be directed against the membrane bound pyridine nucleotide transhydrogenase. If this is the case, the virulent property of this pathogen could be linked to its higher synthesis of NADPH necessary for its anabolism.

Original languageEnglish
Pages (from-to)1073-1079
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume190
Issue number3
DOIs
Publication statusPublished - 15 Feb 1993

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