Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation

Pierre Garin, Chantal Gilain, Jean Philippe Van Damme, Katalin De Fays, Jacques Jamart, Michel Ossemann, Yves Vandermeeren

Research output: Contribution to journalArticle

Abstract

A significant proportion of the population suffers from tinnitus, a bothersome auditory phantom perception that can severely alter the quality of life. Numerous experimental studies suggests that a maladaptive plasticity of the auditory and limbic cortical areas may underlie tinnitus. Accordingly, repetitive transcranial magnetic stimulation (rTMS) has been repeatedly used with success to reduce tinnitus intensity. The potential of transcranial direct current stimulation (tDCS), another promising method of noninvasive brain stimulation, to relieve tinnitus has not been explored systematically. In a double-blind, placebo-controlled and balanced order design, 20 patients suffering from chronic untreatable tinnitus were submitted to 20 minutes of 1 mA anodal, cathodal and sham tDCS targeting the left temporoparietal area. The primary outcome measure was a change in tinnitus intensity or discomfort assessed with a Visual Analogic Scale (VAS) change-scale immediately after tDCS and 1 hour later. Compared to sham tDCS, anodal tDCS significantly reduced tinnitus intensity immediately after stimulation; whereas cathodal tDCS failed to do so. The variances of the tinnitus intensity and discomfort VAS change-scales increased dramatically after anodal and cathodal tDCS, whereas they remained virtually unchanged after sham tDCS. Moreover, several patients unexpectedly reported longer-lasting effects (at least several days) such as tinnitus improvement, worsening, or changes in tinnitus features, more frequently after real than sham tDCS. Anodal tDCS is a promising therapeutic tool for modulating tinnitus perception. Moreover, both anodal and cathodal tDCS seem able to alter tinnitus perception and could, thus, be used to trigger plastic changes.

Original languageEnglish
Pages (from-to)1940-1948
Number of pages9
JournalJournal of Neurology
Volume258
Issue number11
DOIs
Publication statusPublished - 1 Nov 2011
Externally publishedYes

Fingerprint

Tinnitus
Transcranial Direct Current Stimulation
Auditory Perception
Transcranial Magnetic Stimulation
Placebos
Quality of Life
Outcome Assessment (Health Care)

Keywords

  • Brain plasticity
  • Noninvasive brain stimulation
  • Repetitive transcranial magnetic stimulation
  • Tinnitus
  • Transcranial direct current stimulation

Cite this

Garin, Pierre ; Gilain, Chantal ; Van Damme, Jean Philippe ; De Fays, Katalin ; Jamart, Jacques ; Ossemann, Michel ; Vandermeeren, Yves. / Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation. In: Journal of Neurology. 2011 ; Vol. 258, No. 11. pp. 1940-1948.
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Garin, P, Gilain, C, Van Damme, JP, De Fays, K, Jamart, J, Ossemann, M & Vandermeeren, Y 2011, 'Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation', Journal of Neurology, vol. 258, no. 11, pp. 1940-1948. https://doi.org/10.1007/s00415-011-6037-6

Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation. / Garin, Pierre; Gilain, Chantal; Van Damme, Jean Philippe; De Fays, Katalin; Jamart, Jacques; Ossemann, Michel; Vandermeeren, Yves.

In: Journal of Neurology, Vol. 258, No. 11, 01.11.2011, p. 1940-1948.

Research output: Contribution to journalArticle

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