Projects per year
Abstract
Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum. It is endowed with a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity. [1-2] As such, 1 has a strong potential in the anticancer therapy, prompting the development of new derivatives. [3-6] We have turned our attention to the design of a synthetic procedure for 1 performed entirely in
flow, which should enable continuous and rapid production of this useful compound and its derivatives in significant quantities.
Presented in this poster is a crucial step in this synthetic strategy - a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products typically more stable than Z-stilbenes. [7] We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes.
flow, which should enable continuous and rapid production of this useful compound and its derivatives in significant quantities.
Presented in this poster is a crucial step in this synthetic strategy - a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products typically more stable than Z-stilbenes. [7] We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes.
Original language | English |
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Pages | Book of Abstracts, 14th Belgian Organic Synthesis Symposium, P087, p. 136 |
Number of pages | 1 |
Publication status | Published - 13 Jul 2014 |
Event | BOSS XIV - 14th Belgian Organic Synthesis Symposium - Aula Magna, Louvain-la-Neuve, Belgium Duration: 13 Jul 2014 → 18 Jul 2014 |
Conference
Conference | BOSS XIV - 14th Belgian Organic Synthesis Symposium |
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Country | Belgium |
City | Louvain-la-Neuve |
Period | 13/07/14 → 18/07/14 |
Fingerprint Dive into the research topics of 'SELECTIVE SEMIREDUCTION OF ALKYNES AS PART OF AN ENVISAGED CONTINUOUS FLOW SYNTHESIS OF COMBRETASTATIN A-4'. Together they form a unique fingerprint.
Projects
- 1 Finished
Equipment
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Physical Chemistry and characterization(PC2)
Johan Wouters (Manager) & Carmela Aprile (Manager)
Technological Platform Physical Chemistry and characterizationFacility/equipment: Technological Platform
Activities
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Balticum Organicum Syntheticum 2014
Eduard Dolusic (Poster)
6 Jul 2014 → 9 Jul 2014Activity: Participating in or organising an event types › Participation in conference
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BOSS XIV - 14th Belgian Organic Synthesis Symposium
Eduard Dolusic (Poster)
13 Jul 2014 → 18 Jul 2014Activity: Participating in or organising an event types › Participation in conference
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Microfluidics: Fundamentals and Applications - BePCIS symposium
Eduard Dolusic (Participant)
8 May 2014Activity: Participating in or organising an event types › Participation to a Symposium, a study Day