Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response

D. Lis; J. Guthmuller; B. Champagne; C. Humbert; B. Busson; A. Tadjeddine; A. Peremans; F. Cecchet

doi:10.1016/j.cplett.2010.02.061

Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response

D. Lis, J. Guthmuller, B. Champagne, C. Humbert, B. Busson, A. Tadjeddine, A. Peremans, F. Cecchet

Research output: Contribution to journal › Article › peer-review

Abstract

We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.

Original language	English
Pages (from-to)	12-15
Number of pages	4
Journal	Chemical Physics Letters
Volume	489
Issue number	1-3
DOIs	https://doi.org/10.1016/j.cplett.2010.02.061
Publication status	Published - 1 Apr 2010

Access to Document

10.1016/j.cplett.2010.02.061

Cite this

@article{8fac84b192b74a489ca1d4c4161973ca,

title = "Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response",

abstract = "We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.",

author = "D. Lis and J. Guthmuller and B. Champagne and C. Humbert and B. Busson and A. Tadjeddine and A. Peremans and F. Cecchet",

year = "2010",

month = apr,

day = "1",

doi = "10.1016/j.cplett.2010.02.061",

language = "English",

volume = "489",

pages = "12--15",

journal = "Chemical Physics Letters",

issn = "0009-2614",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response

AU - Lis, D.

AU - Guthmuller, J.

AU - Champagne, B.

AU - Humbert, C.

AU - Busson, B.

AU - Tadjeddine, A.

AU - Peremans, A.

AU - Cecchet, F.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.

AB - We have investigated a metal-supported lipid film by using a sum frequency generation (SFG) spectrometer coupled to a free electron laser (FEL). DFT calculations on a molecular model have enabled to assign the vibrational signatures. The SFG vibrations detected in the backbone region, between 1375 cm and 1000 cm, originate from the vibrational motions of the 2,4-dinitrophenyl polar head of the lipid, which holds antigenic properties, and can therefore be used to selectively study the biological interactions with complementary antibodies. Theses results strengthen the role of SFG spectroscopy as a highly sensitive tool for biological detection.

UR - http://www.scopus.com/inward/record.url?scp=77949485901&partnerID=8YFLogxK

U2 - 10.1016/j.cplett.2010.02.061

DO - 10.1016/j.cplett.2010.02.061

M3 - Article

AN - SCOPUS:77949485901

SN - 0009-2614

VL - 489

SP - 12

EP - 15

JO - Chemical Physics Letters

JF - Chemical Physics Letters

IS - 1-3

ER -

Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response

Abstract

Access to Document

Other files and links

Fingerprint

Optics, Lasers and spectroscopy

Action Nationale de Formation du CNRS en "Spectroscopie et Imagerie d’interfaces materiaux- molecules du vivant"

Cite this

Selective detection of the antigenic polar heads of model lipid membranes supported on metals from their vibrational nonlinear optical response

Abstract

Access to Document

Other files and links

Fingerprint

Equipment

Optics, Lasers and spectroscopy

Activities

Action Nationale de Formation du CNRS en "Spectroscopie et Imagerie d’interfaces materiaux- molecules du vivant"

Cite this