Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Jan Schuemann, Alexander Bagley, Ross Berbeco, Kyle Bromma, Karl T Butterworth, Hilary Byrne, Devika B Chithrani, Sang Hyun Cho, Jason R Cook, Vincent Favaudon, Yaser Hadi Gholami, Elisabetta Gargioni, James F Hainfeld, Félicien Hespeels, Anne-Catherine Heuskin, Udoka Maverick Ibeh, Zdenka Kuncic, Sijumon Kunjachan, Sandrine Lacombe, Stephane LucasFrancois Lux, Stephen J McMahon, Dmitry Nevozhay, Wilfred Ngwa, J Donald Payne, Sébastien Penninckx, Erika Porcel, Kevin M Prise, Hans Rabus, Sharif M Ridwan, Benedikt Rudek, Leon Sanche, Bijay Singh, Henry M Smilowitz, Konstantin V Sokolov, Srinivas Sridhar, Yaroslav Stanishevskiy, Wonmo Sung, Olivier Tillement, Needa Alnoor Virani, Wassana Yantasee, Sunil Krishnan

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This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

Original languageEnglish
Article number21RM02
Number of pages129
JournalPhysics in Medicine and Biology
Issue number21
Early online date2020
Publication statusPublished - 7 Nov 2020


  • immunotherapy
  • metal nanoparticles
  • modeling
  • nanoparticle imaging
  • radiotherapy
  • theranostics
  • therapeutic applications of nanoparticles
  • Metal Nanoparticles/therapeutic use
  • Humans
  • Hyperthermia, Induced
  • Theranostic Nanomedicine/methods

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