Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Jan Schuemann; Alexander Bagley; Ross Berbeco; Kyle Bromma; Karl T Butterworth; Hilary Byrne; Devika B Chithrani; Sang Hyun Cho; Jason R Cook; Vincent Favaudon; Yaser Hadi Gholami; Elisabetta Gargioni; James F Hainfeld; Félicien Hespeels; Anne-Catherine Heuskin; Udoka Maverick Ibeh; Zdenka Kuncic; Sijumon Kunjachan; Sandrine Lacombe; Stephane Lucas; Francois Lux; Stephen J McMahon; Dmitry Nevozhay; Wilfred Ngwa; J Donald Payne; Sébastien Penninckx; Erika Porcel; Kevin M Prise; Hans Rabus; Sharif M Ridwan; Benedikt Rudek; Leon Sanche; Bijay Singh; Henry M Smilowitz; Konstantin V Sokolov; Srinivas Sridhar; Yaroslav Stanishevskiy; Wonmo Sung; Olivier Tillement; Needa Alnoor Virani; Wassana Yantasee; Sunil Krishnan

doi:10.1088/1361-6560/ab9159

Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Jan Schuemann, Alexander Bagley, Ross Berbeco, Kyle Bromma, Karl T Butterworth, Hilary Byrne, Devika B Chithrani, Sang Hyun Cho, Jason R Cook, Vincent Favaudon, Yaser Hadi Gholami, Elisabetta Gargioni, James F Hainfeld, Félicien Hespeels, Anne-Catherine Heuskin, Udoka Maverick Ibeh, Zdenka Kuncic, Sijumon Kunjachan, Sandrine Lacombe, Stephane LucasFrancois Lux, Stephen J McMahon, Dmitry Nevozhay, Wilfred Ngwa, J Donald Payne, Sébastien Penninckx, Erika Porcel, Kevin M Prise, Hans Rabus, Sharif M Ridwan, Benedikt Rudek, Leon Sanche, Bijay Singh, Henry M Smilowitz, Konstantin V Sokolov, Srinivas Sridhar, Yaroslav Stanishevskiy, Wonmo Sung, Olivier Tillement, Needa Alnoor Virani, Wassana Yantasee, Sunil Krishnan

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Abstract

This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

Original language	English
Article number	21RM02
Number of pages	129
Journal	Physics in Medicine and Biology
Volume	65
Issue number	21
Early online date	2020
DOIs	https://doi.org/10.1088/1361-6560/ab9159
Publication status	Published - 7 Nov 2020

Keywords

immunotherapy
metal nanoparticles
modeling
nanoparticle imaging
radiotherapy
theranostics
therapeutic applications of nanoparticles
Metal Nanoparticles/therapeutic use
Humans
Hyperthermia, Induced
Theranostic Nanomedicine/methods

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/1361-6560/ab9159

2020_HespeelsHeuskinLucasPenninckx_articleAccepted author manuscript, 12.4 MB

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Schuemann, J., Bagley, A., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D. B., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y. H., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., ... Krishnan, S. (2020). Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Physics in Medicine and Biology, 65(21), [21RM02]. https://doi.org/10.1088/1361-6560/ab9159

Schuemann, Jan ; Bagley, Alexander ; Berbeco, Ross ; Bromma, Kyle ; Butterworth, Karl T ; Byrne, Hilary ; Chithrani, Devika B ; Cho, Sang Hyun ; Cook, Jason R ; Favaudon, Vincent ; Gholami, Yaser Hadi ; Gargioni, Elisabetta ; Hainfeld, James F ; Hespeels, Félicien ; Heuskin, Anne-Catherine ; Ibeh, Udoka Maverick ; Kuncic, Zdenka ; Kunjachan, Sijumon ; Lacombe, Sandrine ; Lucas, Stephane ; Lux, Francois ; McMahon, Stephen J ; Nevozhay, Dmitry ; Ngwa, Wilfred ; Payne, J Donald ; Penninckx, Sébastien ; Porcel, Erika ; Prise, Kevin M ; Rabus, Hans ; Ridwan, Sharif M ; Rudek, Benedikt ; Sanche, Leon ; Singh, Bijay ; Smilowitz, Henry M ; Sokolov, Konstantin V ; Sridhar, Srinivas ; Stanishevskiy, Yaroslav ; Sung, Wonmo ; Tillement, Olivier ; Virani, Needa Alnoor ; Yantasee, Wassana ; Krishnan, Sunil. / Roadmap for metal nanoparticles in radiation therapy : current status, translational challenges, and future directions. In: Physics in Medicine and Biology. 2020 ; Vol. 65, No. 21.

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title = "Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions",

abstract = "This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.",

keywords = "immunotherapy, metal nanoparticles, modeling, nanoparticle imaging, radiotherapy, theranostics, therapeutic applications of nanoparticles, Metal Nanoparticles/therapeutic use, Humans, Hyperthermia, Induced, Theranostic Nanomedicine/methods",

author = "Jan Schuemann and Alexander Bagley and Ross Berbeco and Kyle Bromma and Butterworth, {Karl T} and Hilary Byrne and Chithrani, {Devika B} and Cho, {Sang Hyun} and Cook, {Jason R} and Vincent Favaudon and Gholami, {Yaser Hadi} and Elisabetta Gargioni and Hainfeld, {James F} and F{\'e}licien Hespeels and Anne-Catherine Heuskin and Ibeh, {Udoka Maverick} and Zdenka Kuncic and Sijumon Kunjachan and Sandrine Lacombe and Stephane Lucas and Francois Lux and McMahon, {Stephen J} and Dmitry Nevozhay and Wilfred Ngwa and Payne, {J Donald} and S{\'e}bastien Penninckx and Erika Porcel and Prise, {Kevin M} and Hans Rabus and Ridwan, {Sharif M} and Benedikt Rudek and Leon Sanche and Bijay Singh and Smilowitz, {Henry M} and Sokolov, {Konstantin V} and Srinivas Sridhar and Yaroslav Stanishevskiy and Wonmo Sung and Olivier Tillement and Virani, {Needa Alnoor} and Wassana Yantasee and Sunil Krishnan",

note = "Publisher Copyright: {\textcopyright} 2020 Institute of Physics and Engineering in Medicine.",

year = "2020",

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doi = "10.1088/1361-6560/ab9159",

language = "English",

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Schuemann, J, Bagley, A, Berbeco, R, Bromma, K, Butterworth, KT, Byrne, H, Chithrani, DB, Cho, SH, Cook, JR, Favaudon, V, Gholami, YH, Gargioni, E, Hainfeld, JF, Hespeels, F , Heuskin, A-C, Ibeh, UM, Kuncic, Z, Kunjachan, S, Lacombe, S, Lucas, S, Lux, F, McMahon, SJ, Nevozhay, D, Ngwa, W, Payne, JD, Penninckx, S, Porcel, E, Prise, KM, Rabus, H, Ridwan, SM, Rudek, B, Sanche, L, Singh, B, Smilowitz, HM, Sokolov, KV, Sridhar, S, Stanishevskiy, Y, Sung, W, Tillement, O, Virani, NA, Yantasee, W & Krishnan, S 2020, 'Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions', Physics in Medicine and Biology, vol. 65, no. 21, 21RM02. https://doi.org/10.1088/1361-6560/ab9159

Roadmap for metal nanoparticles in radiation therapy : current status, translational challenges, and future directions. / Schuemann, Jan; Bagley, Alexander; Berbeco, Ross; Bromma, Kyle; Butterworth, Karl T; Byrne, Hilary; Chithrani, Devika B; Cho, Sang Hyun; Cook, Jason R; Favaudon, Vincent; Gholami, Yaser Hadi; Gargioni, Elisabetta; Hainfeld, James F; Hespeels, Félicien ; Heuskin, Anne-Catherine; Ibeh, Udoka Maverick; Kuncic, Zdenka; Kunjachan, Sijumon; Lacombe, Sandrine; Lucas, Stephane; Lux, Francois; McMahon, Stephen J; Nevozhay, Dmitry; Ngwa, Wilfred; Payne, J Donald; Penninckx, Sébastien; Porcel, Erika; Prise, Kevin M; Rabus, Hans; Ridwan, Sharif M; Rudek, Benedikt; Sanche, Leon; Singh, Bijay; Smilowitz, Henry M; Sokolov, Konstantin V; Sridhar, Srinivas; Stanishevskiy, Yaroslav; Sung, Wonmo; Tillement, Olivier; Virani, Needa Alnoor; Yantasee, Wassana; Krishnan, Sunil.

In: Physics in Medicine and Biology, Vol. 65, No. 21, 21RM02, 07.11.2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Roadmap for metal nanoparticles in radiation therapy

T2 - current status, translational challenges, and future directions

AU - Schuemann, Jan

AU - Bagley, Alexander

AU - Berbeco, Ross

AU - Bromma, Kyle

AU - Butterworth, Karl T

AU - Byrne, Hilary

AU - Chithrani, Devika B

AU - Cho, Sang Hyun

AU - Cook, Jason R

AU - Favaudon, Vincent

AU - Gholami, Yaser Hadi

AU - Gargioni, Elisabetta

AU - Hainfeld, James F

AU - Hespeels, Félicien

AU - Heuskin, Anne-Catherine

AU - Ibeh, Udoka Maverick

AU - Kuncic, Zdenka

AU - Kunjachan, Sijumon

AU - Lacombe, Sandrine

AU - Lucas, Stephane

AU - Lux, Francois

AU - McMahon, Stephen J

AU - Nevozhay, Dmitry

AU - Ngwa, Wilfred

AU - Payne, J Donald

AU - Penninckx, Sébastien

AU - Porcel, Erika

AU - Prise, Kevin M

AU - Rabus, Hans

AU - Ridwan, Sharif M

AU - Rudek, Benedikt

AU - Sanche, Leon

AU - Singh, Bijay

AU - Smilowitz, Henry M

AU - Sokolov, Konstantin V

AU - Sridhar, Srinivas

AU - Stanishevskiy, Yaroslav

AU - Sung, Wonmo

AU - Tillement, Olivier

AU - Virani, Needa Alnoor

AU - Yantasee, Wassana

AU - Krishnan, Sunil

PY - 2020/11/7

Y1 - 2020/11/7

N2 - This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

AB - This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

KW - immunotherapy

KW - metal nanoparticles

KW - modeling

KW - nanoparticle imaging

KW - radiotherapy

KW - theranostics

KW - therapeutic applications of nanoparticles

KW - Metal Nanoparticles/therapeutic use

KW - Humans

KW - Hyperthermia, Induced

KW - Theranostic Nanomedicine/methods

UR - http://www.scopus.com/inward/record.url?scp=85088559395&partnerID=8YFLogxK

U2 - 10.1088/1361-6560/ab9159

DO - 10.1088/1361-6560/ab9159

M3 - Article

C2 - 32380492

VL - 65

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 21

M1 - 21RM02

ER -

Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Abstract

Keywords

UN SDGs

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Synthesis, Irradiation and Analysis of Materials (SIAM)

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Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Abstract

Keywords

UN SDGs

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Synthesis, Irradiation and Analysis of Materials (SIAM)

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