Activities per year
Abstract
Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis, and recurrence after treatment. Macrophage plasticity and diversity allow their classification along a M1-M2 polarization axis. Tumor-associated macrophages usually display a M2-like phenotype, associated with pro-tumoral features whereas M1 macrophages exert antitumor functions. Targeting the reprogramming of TAMs toward M1-like macrophages would thus be an efficient way to promote tumor regression. This can be achieved through therapies including chemotherapy, immunotherapy, and radiotherapy (RT). In this review, we first describe how chemo- and immunotherapies can target TAMs and, second, we detail how RT modifies macrophage phenotype and present the molecular pathways that may be involved. The identification of irradiation dose inducing macrophage reprogramming and of the underlying mechanisms could lead to the design of novel therapeutic strategies and improve synergy in combined treatments.
Original language | English |
---|---|
Article number | 828 |
Pages (from-to) | 828 |
Number of pages | 19 |
Journal | Frontiers in Immunology |
Volume | 8 |
Issue number | JUL |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Chemotherapy
- Nuclear factor kappa B
- Polarization immunotherapy
- Radiotherapy
- Reactive oxygen species
- Reprogramming
- Tumor-associated macrophages
Fingerprint
Dive into the research topics of 'Reprogramming of tumor-associated macrophages with anticancer therapies: Radiotherapy versus chemo- and immunotherapies'. Together they form a unique fingerprint.Equipment
-
Synthesis, Irradiation and Analysis of Materials (SIAM)
Louette, P. (Manager), Colaux, J. (Manager), Felten, A. (Manager), Tabarrant, T. (Operator), COME, F. (Operator) & Debarsy, P.-L. (Manager)
Technological Platform Synthesis, Irradiation and Analysis of MaterialsFacility/equipment: Technological Platform
Activities
- 1 Participation in conference
-
63rd annual Congress of the Radiation Research Society
Lucas, S. (Poster)
15 Oct 2017 → 18 Oct 2017Activity: Participating in or organising an event types › Participation in conference
Student theses
-
Unravelling the effects of proton irradiation on macrophages in cancer
Genard, G. (Author)Michiels, C. (Supervisor), Heuskin, A.-C. (President), Lucas, S. (Jury), Poumay, Y. (Jury), Feron, O. (Jury) & Huber, P. (Jury), 30 May 2018Student thesis: Doc types › Doctor of Sciences
File