Regioselective Synthesis of Difluorinated C-Furanosides Involving a Debenzylative Cycloetherification

Julien A. Delbrouck, Valentin N. Bochatay, Abdellatif Tikad, Stéphane P. Vincent

Research output: Contribution to journalArticlepeer-review


A highly regioselective synthesis of valuable gem-difluorinated C-furanosides from unprotected aldoses via a debenzylative cycloetherification (DBCE) reaction induced by diethylaminosulfur trifluoride is descibed. The scope and limitations of this DBCE reaction are described using a series of commercially available pentoses and hexoses to afford, without selective protection/deprotection sequences, the corresponding gem-difluorinated C-furanosides in moderate to good yields.

Original languageEnglish
Pages (from-to)5562-5566
Number of pages5
JournalOrganic Letters
Issue number14
Publication statusPublished - 5 Jul 2019


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