Regio and stereochemically controlled ring opening of epoxides with grignard reagents. Stereocontrolled synthesis of the steroid side chains. first stereoselective hemisynthesis of 20s isolanosterol.

J.R. Schauder, A. Krief

    Research output: Contribution to journalArticle

    Abstract

    Title compound was efficiently prepared taking advantage of a stereoselective hydride shift during the reaction between the Grignard reagent derived from ethoxyacetylene and an epoxide. The solvent was found to have a crucial role in this and related reactions.
    Original languageEnglish
    Pages (from-to)4389-4392
    Number of pages4
    JournalTetrahedron Letters
    Volume23
    Issue number42
    Publication statusPublished - 1 Jan 1982

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