TY - JOUR
T1 - Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan
AU - DIMITRA Research Group
AU - Belmans, Niels
AU - Gilles, Liese
AU - Vermeesen, Randy
AU - Virag, Piroska
AU - Hedesiu, Mihaela
AU - Salmon, Benjamin
AU - Baatout, Sarah
AU - Lucas, Stéphane
AU - Lambrichts, Ivo
AU - Jacobs, Reinhilde
AU - Moreels, Marjan
AU - Oenning, A. C.
AU - Chaussain, C.
AU - Lefevre, C.
AU - Baciut, M.
AU - Marcu, M.
AU - Almasan, O.
AU - Roman, R.
AU - Barbur, I.
AU - Dinu, C.
AU - Rotaru, H.
AU - Hurubeanu, L.
AU - Istouan, V.
AU - Lucaciu, O.
AU - Leucuta, D.
AU - Crisan, B.
AU - Bogdan, L.
AU - Candea, C.
AU - Bran, S.
AU - Baciut, G.
AU - Bosmans, H.
AU - Bogaerts, R.
AU - Politis, C.
AU - Stratis, A.
AU - Pauwels, R.
AU - Vasconcelos, K. de F.
AU - Nicolielo, L.
AU - Zhang, G.
AU - Tijskens, E.
AU - Vranckx, M.
AU - Ockerman, A.
AU - Claerhout, E.
AU - Embrechts, E.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.
AB - Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.
UR - http://www.scopus.com/inward/record.url?scp=85079083727&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-58746-5
DO - 10.1038/s41598-020-58746-5
M3 - Article
C2 - 32034200
AN - SCOPUS:85079083727
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 2113
ER -