Prothrombotic Hemostasis Disturbances in Patients with Severe COVID-19: Individual daily data

Michaël Hardy, Isabelle Michaux, Sarah Lessire, Jonathan Douxfils, Jean-Michel Dogné, Marion Bareille, Geoffrey Horlait, Pierre Bulpa, Celine Chapelle, Silvy Laporte, Sophie Testa, Hugues Jacqmin, Thomas Lecompte, Alain Dive, François Mullier

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Abstract

This data article accompanies the manuscript entitled: "Prothrombotic Disturbances of Hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Cohort Study" submitted to Thrombosis Research by the same authors. We report temporal changes of plasma levels of an extended set of laboratory parameters during the ICU stay of the 21 COVID-19 patients included in the monocentre cohort: CRP, platelet count, prothrombin time; Clauss fibrinogen and clotting factors II, V and VIII levels, D-dimers, antithrombin activity, protein C, free protein S, total and free tissue factor pathway inhibitor, PAI-1 levels, von Willebrand factor antigen and activity, ADAMTS-13 (plasma levels); and of two integrative tests of coagulation (thrombin generation ST Genesia) and fibrinolysis (global fibrinolytic capacity - GFC). Regarding hemostasis, we used double-centrifuged frozen citrated plasma prospectively collected after daily performance of usual coagulation tests. Demographic and clinical characteristics of patients and thrombotic and hemorrhagic complications were also collected from patient's electronic medical reports.

Original languageEnglish
Pages (from-to)106519
Number of pages26
JournalData in Brief
DOIs
Publication statusE-pub ahead of print - 2020

Keywords

  • covid-19
  • Intensive Care Units
  • thrombin generation
  • Fibrinolysis
  • D-dimers
  • hemostasis plasma proteins

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