Protein pattern transfer for biosensor applications

C. Volcke, R.P. Gandhiraman, L. Basabe-Desmonts, M. Iacono, V. Gubala, F. Cecchet, A.A. Cafolla, D.E. Williams

    Research output: Contribution to journalArticle


    This paper presents a very simple, industrially scalable method for transferring a high-resolution, biologically active protein pattern from one substrate to another. We demonstrate the transfer of a protein pattern formed initially by microcontact printing from a silicon surface (to which this form of printing is applicable) onto a glass or polymer substrate, almost independently of the surface/bulk properties of the second substrate. A very thin, spin-coated layer of a sugar is used to preserve the structure and organization of proteins during the subsequent plasma deposition of a siloxane polymer, after which the protein pattern could simply be peeled off the silicon substrate and glued onto any other desired substrate.
    Original languageEnglish
    Pages (from-to)1295-1300
    Number of pages6
    JournalBiosensors and Bioelectronics
    Issue number6
    Publication statusPublished - 15 Feb 2010

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    Volcke, C., Gandhiraman, R. P., Basabe-Desmonts, L., Iacono, M., Gubala, V., Cecchet, F., Cafolla, A. A., & Williams, D. E. (2010). Protein pattern transfer for biosensor applications. Biosensors and Bioelectronics, 25(6), 1295-1300.