Prognostic value of intracoronary flow velocity and diameter stenosis in assessing the short and long-term outcomes of coronary balloon angioplasty: The DEBATE study (Doppler Endpoints Balloon Angioplasty Trial Europe)

Patrick W. Serruys, Carlo Di Mario, Jan Piek, Erwin Schroeder, Christian Vrints, Peter Probst, Bernard De Bruyne, Claude Hanet, Eckart Fleck, Michael Haude, Edoardo Verna, Vasilis Voudris, Herbert Geschwind, Håkan Emanuelsson, V. Mühlberger, Giambattista Danzi, Hans O. Peels, Andrew J. Ford, Eric Boersma

    Research output: Contribution to journalArticle

    Abstract

    Background: The aim of this prospective, multicenter study was the identification of Doppler flow velocity measurements predictive of clinical outcome of patients undergoing single-vessel balloon angioplasty with no previous Q-wave myocardial infarction. Methods and Results: In 297 patients, a Doppler guidewire was used to measure basal and maximal hyperemic flow velocities proximal and distal to the stenosis before and after angioplasty. In 225 patients with an angiographically successful percutaneous transluminal coronary angioplasty (PTCA), post-procedural distal coronary flow reserve (CFR) and percent diameter stenosis (DS%) were correlated with symptoms and/or ischemia at 1 and 6 months, with the need for target lesion revascularization, and with angiographic restenosis (defined as DS ≤50% at follow-up). Logistic regression and receiver operator characteristic curve analyses were applied to determine the prognostic cutoff value of CFR and DS separately and in combination. Optimal cutoff criteria for predictors of these clinical events were DS, 35%; CFR, 2.5. A distal CFR after angioplasty >2.5 with a residual DS ≤35% identified lesions with a low incidence of recurrence of symptoms at i month (10% versus 19%, P=.149) and at 6 months (23% versus 47%, P=.005), a low need for reintervention (16% versus 34%, P=.024), and a low restenosis rate (16% versus 41%, P=.002) compared with patients who did not meet these criteria. Conclusions: Measurements of distal CFR after PTCA, in combination with DS%, have a predictive value, albeit modest for the short- and long-term outcomes after PTCA, and thus may be used to identify patients who will or will not benefit from additional therapy such as stent implantation.

    Original languageEnglish
    Pages (from-to)3369-3377
    Number of pages9
    JournalCirculation
    Volume96
    Issue number10
    DOIs
    Publication statusPublished - 18 Nov 1997

    Keywords

    • Angioplasty
    • Balloon
    • Prognosis
    • Stenosis

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    Serruys, P. W., Di Mario, C., Piek, J., Schroeder, E., Vrints, C., Probst, P., De Bruyne, B., Hanet, C., Fleck, E., Haude, M., Verna, E., Voudris, V., Geschwind, H., Emanuelsson, H., Mühlberger, V., Danzi, G., Peels, H. O., Ford, A. J., & Boersma, E. (1997). Prognostic value of intracoronary flow velocity and diameter stenosis in assessing the short and long-term outcomes of coronary balloon angioplasty: The DEBATE study (Doppler Endpoints Balloon Angioplasty Trial Europe). Circulation, 96(10), 3369-3377. https://doi.org/10.1161/01.CIR.96.10.3369