Pristine multi-walled carbon nanotubes/SDS modified carbon paste electrode as an amperometric sensor for epinephrine

Tony Thomas, Ronald J. Mascarenhas, Ozma J. D'Souza, Simon Detriche, Zineb Mekhalif, Praveen Martis

Research output: Contribution to journalArticle

Abstract

An amperometric sensor for the determination of epinephrine (EP) was fabricated by modifying the carbon paste electrode (CPE) with pristine multi-walled carbon nanotubes (pMWCNTs) using bulk modification followed by drop casting of sodium dodecyl sulfate (SDS) onto the surface for its optimal potential application. The modified electrode showed an excellent electrocatalytic activity towards EP by decreasing the overpotential and greatly enhancing the current sensitivity. FE-SEM images confirmed the dispersion of pMWCNTs in the CPE matrix. EDX analysis ensured the surface coverage of SDS. A comparative study of pMWCNTs with those of oxidized MWCNTs (MWCNTsOX) modified electrodes reveals that the former is the best base material for the construction of the sensor with advantages of lower oxidation overpotential and the least background current. The performance of the modified electrode was impressive in terms of the least charge transfer resistance (Rct), highest values for diffusion coefficient (DEP) and standard heterogeneous electron transfer rate constant (k°). Analytical characterization of the modified electrode exhibited two linear dynamic ranges from 1.0×10-7 to 1.0×10-6 M and 1.0×10-6 to 1.0×10-4 M with a detection limit of (4.5±0.18)×10-8 M. A 100-fold excess of serotonin, acetaminophen, folic acid, uric acid, tryptophan, tyrosine and cysteine, 10-fold excess of ascorbic acid and twofold excess of dopamine do not interfere in the quantification of EP at this electrode. The analytical applications of the modified electrode were demonstrated by determining EP in spiked blood serum and adrenaline tartrate injection. The modified electrode involves a simple fabrication procedure, minimum usage of the modifier, quick response, excellent stability, reproducibility and anti-fouling effects.

Original languageEnglish
Pages (from-to)352-360
Number of pages9
JournalTalanta
Volume125
DOIs
Publication statusPublished - 1 Jul 2014

Fingerprint

Amperometric sensors
Carbon Nanotubes
Ointments
Sodium Dodecyl Sulfate
Epinephrine
Electrodes
Carbon
Acetaminophen
Fouling
Uric Acid
Folic Acid
Tryptophan
Ascorbic Acid
Cysteine
Tyrosine
Limit of Detection
Charge transfer
Energy dispersive spectroscopy
Rate constants
Dopamine

Keywords

  • Diffusion coefficient
  • Epinephrine
  • Modified carbon paste electrode
  • Multi-walled carbon nanotubes
  • Sodium dodecyl sulfate

Cite this

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title = "Pristine multi-walled carbon nanotubes/SDS modified carbon paste electrode as an amperometric sensor for epinephrine",
abstract = "An amperometric sensor for the determination of epinephrine (EP) was fabricated by modifying the carbon paste electrode (CPE) with pristine multi-walled carbon nanotubes (pMWCNTs) using bulk modification followed by drop casting of sodium dodecyl sulfate (SDS) onto the surface for its optimal potential application. The modified electrode showed an excellent electrocatalytic activity towards EP by decreasing the overpotential and greatly enhancing the current sensitivity. FE-SEM images confirmed the dispersion of pMWCNTs in the CPE matrix. EDX analysis ensured the surface coverage of SDS. A comparative study of pMWCNTs with those of oxidized MWCNTs (MWCNTsOX) modified electrodes reveals that the former is the best base material for the construction of the sensor with advantages of lower oxidation overpotential and the least background current. The performance of the modified electrode was impressive in terms of the least charge transfer resistance (Rct), highest values for diffusion coefficient (DEP) and standard heterogeneous electron transfer rate constant (k°). Analytical characterization of the modified electrode exhibited two linear dynamic ranges from 1.0×10-7 to 1.0×10-6 M and 1.0×10-6 to 1.0×10-4 M with a detection limit of (4.5±0.18)×10-8 M. A 100-fold excess of serotonin, acetaminophen, folic acid, uric acid, tryptophan, tyrosine and cysteine, 10-fold excess of ascorbic acid and twofold excess of dopamine do not interfere in the quantification of EP at this electrode. The analytical applications of the modified electrode were demonstrated by determining EP in spiked blood serum and adrenaline tartrate injection. The modified electrode involves a simple fabrication procedure, minimum usage of the modifier, quick response, excellent stability, reproducibility and anti-fouling effects.",
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Pristine multi-walled carbon nanotubes/SDS modified carbon paste electrode as an amperometric sensor for epinephrine. / Thomas, Tony; Mascarenhas, Ronald J.; D'Souza, Ozma J.; Detriche, Simon; Mekhalif, Zineb; Martis, Praveen.

In: Talanta, Vol. 125, 01.07.2014, p. 352-360.

Research output: Contribution to journalArticle

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T1 - Pristine multi-walled carbon nanotubes/SDS modified carbon paste electrode as an amperometric sensor for epinephrine

AU - Thomas, Tony

AU - Mascarenhas, Ronald J.

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AU - Mekhalif, Zineb

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