Abstract
Mesenchymal stem cells are increasingly studied for their use as drug-carrier in addition to their intrinsic potential for regenerative medicine. They could be used to transport molecules with a poor bioavailability such as curcumin in order to improve their clinical usage. This natural polyphenol, well-known for its antioxidant and anti-inflammatory properties, has a poor solubility that limits its clinical potential. For this purpose, the use of NDS27, a curcumin salt complexed with hydroxypropyl-beta-cyclodextrin (HPβCD), displaying an increased solubility in aqueous solution, is preferred. This study aims to evaluate the uptake of NDS27 into skeletal muscle-derived mesenchymal stem cells (mdMSCs) and the effects of such uptake onto their mesenchymal properties. It appeared that the uptake of NDS27 into mdMSCs is concentration-dependent and not time-dependent. The use of a concentration of 7 µmol/L which does not affect the viability and proliferation also allows preservation of their adhesion, invasion and T cell immunomodulatory abilities.
Original language | English |
---|---|
Pages (from-to) | 4877-4881 |
Number of pages | 5 |
Journal | Journal of Cellular and Molecular Medicine |
Volume | 25 |
Issue number | 10 |
Early online date | 26 Mar 2021 |
DOIs | |
Publication status | Published - May 2021 |
Keywords
- curcumin
- cyclodextrin
- equine MSCs
- mdMSC
- mesenchymal stem cells
- mitochondria
- NDS27