TY - PAT
T1 - Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents
AU - De Jonghe, Steven
AU - Dolusic, Eduard
AU - Gao, Ling-Jie
AU - Herdewijn, Piet
AU - Pfleiderer, Wolfgang
PY - 2009/1/8
Y1 - 2009/1/8
N2 - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-a related disorders, viral diseases (including hepatitis C)1 erectile dysfunction and cell proliferative disorders.
AB - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-a related disorders, viral diseases (including hepatitis C)1 erectile dysfunction and cell proliferative disorders.
M3 - Patent
M1 - WO2009003669 (A2)
ER -