Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Steven De Jonghe; Eduard Dolusic; Ling-Jie Gao; Piet Herdewijn; Wolfgang Pfleiderer

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Steven De Jonghe (Inventor), Eduard Dolusic (Inventor), Ling-Jie Gao (Inventor), Piet Herdewijn (Inventor), Wolfgang Pfleiderer (Inventor)

Namur Research Institute for Life Sciences

Research output: Patent

Abstract

This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-a related disorders, viral diseases (including hepatitis C)1 erectile dysfunction and cell proliferative disorders.

Original language	English
Patent number	WO2009003669 (A2)
IPC	A61K31/519; A61P35/00; C07D471/04
Publication status	Published - 8 Jan 2009

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This output contributes to the following UN Sustainable Development Goals (SDGs)

3 Patent

Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 5 Feb 2009, IPC No. A61K31/496; A61K31/519; A61K31/5377; A61K31/551; A61P17/00; A61P19/02; A61P37/06; C07D243/08; C07D413/14; C07D471/02, Patent No. US2009036430 (A1)
Research output: Patent
Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 3 Jan 2008, IPC No. A61K31/519; C07D471/04; C07D487/02, Patent No. US2008004285 (A1)
Research output: Patent
Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs
De Jonghe, S., Dolusic, E., Gao, L-J., Herdewijn, P. & Pfleiderer, W., 6 Jul 2006, IPC No. C07D471/04, Patent No. WO2006069805 (A2)
Research output: Patent

Cite this

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title = "Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents",

abstract = "This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-a related disorders, viral diseases (including hepatitis C)1 erectile dysfunction and cell proliferative disorders.",

author = "{De Jonghe}, Steven and Eduard Dolusic and Ling-Jie Gao and Piet Herdewijn and Wolfgang Pfleiderer",

year = "2009",

month = jan,

day = "8",

language = "English",

type = "Patent",

note = "WO2009003669 (A2); A61K31/519; A61P35/00; C07D471/04",

}

TY - PAT

T1 - Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

AU - De Jonghe, Steven

AU - Dolusic, Eduard

AU - Gao, Ling-Jie

AU - Herdewijn, Piet

AU - Pfleiderer, Wolfgang

PY - 2009/1/8

Y1 - 2009/1/8

N2 - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-a related disorders, viral diseases (including hepatitis C)1 erectile dysfunction and cell proliferative disorders.

AB - This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-a related disorders, viral diseases (including hepatitis C)1 erectile dysfunction and cell proliferative disorders.

M3 - Patent

M1 - WO2009003669 (A2)

ER -

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Abstract

UN SDGs

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Research output

Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs

Cite this