Preliminary results of proton beam characterization for a facility of broad beam in vitro cell irradiation

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Abstract

The interaction of charged particles with living matter needs to be well understood for medical applications. Particularly, it is useful to study how ion beams interact with tissues in terms of damage, dose released and dose rate. One way to evaluate the biological effects induced by an ion beam is by the irradiation of cultured cells at a particle accelerator, where cells can be exposed to different ions at different energies and flux. In this paper, we report the first results concerning the characterization of a broad proton beam obtained with our 2 MV tandem accelerator. For broad beam in vitro cell irradiation, the beam has to be stable over time, uniform over a ∼0.5 cm surface, and a dose rate ranging from 0.1 to 10 Gy/min must be achievable. Results concerning the level of achievement of these requirements are presented in this paper for a 1 MeV proton beam. © 2008 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)2122-2124
Number of pages3
JournalNuclear instruments and methods in physics research B
Volume266
Issue number10
DOIs
Publication statusPublished - 1 May 2008

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