Abstract
Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.
Original language | English |
---|---|
Pages (from-to) | 135-157 |
Number of pages | 23 |
Journal | Current Opinion in Colloid and Interface Science |
Volume | 38 |
DOIs | |
Publication status | Published - 1 Nov 2018 |
Funding
This work was supported by the National Key Research and Development Program of China ( 2016YFA0102200 ), Chinese Ministry of Education in a frame work of the Changjiang Scholar Innovation Research Team Program ( IRT_15R52 ), “ Algae Factory ” ( 1610187 ) European H2020 program financed by FEDER and Wallonia Region of Belgium .
Funders | Funder number |
---|---|
Changjiang Scholar Innovation Research Team Program | 1610187 |
Wallonia Region of Belgium | |
Ministry of Education of the People's Republic of China | |
Federación Española de Enfermedades Raras | |
Changjiang Scholar Program of Chinese Ministry of Education | IRT_15R52 |
European Regional Development Fund | |
National Key Research and Development Program of China | 2016YFA0102200 |
Keywords
- Cell encapsulation
- Cell therapy
- Hydrogels
- Porosity
- Stimuli-responsivity
Fingerprint
Dive into the research topics of 'Porous and responsive hydrogels for cell therapy'. Together they form a unique fingerprint.Equipment
-
Physical Chemistry and characterization(PC2)
Wouters, J. (Manager), Aprile, C. (Manager) & Fusaro, L. (Manager)
Technological Platform Physical Chemistry and characterizationFacility/equipment: Technological Platform