Abstract
Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 135-157 |
| Number of pages | 23 |
| Journal | Current Opinion in Colloid and Interface Science |
| Volume | 38 |
| DOIs | |
| Publication status | Published - 1 Nov 2018 |
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Keywords
- Cell encapsulation
- Cell therapy
- Hydrogels
- Porosity
- Stimuli-responsivity
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Porous and responsive hydrogels for cell therapy. / Wang, Li; Neumann, Myriam; Fu, Tianlong; Li, Weida; Cheng, Xin; Su, Bao Lian.
In: Current Opinion in Colloid and Interface Science, Vol. 38, 01.11.2018, p. 135-157.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Porous and responsive hydrogels for cell therapy
AU - Wang, Li
AU - Neumann, Myriam
AU - Fu, Tianlong
AU - Li, Weida
AU - Cheng, Xin
AU - Su, Bao Lian
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.
AB - Cell therapy is an emerging and promising regenerative approach by cell replacement for the treatment of diseases or injuries. Hydrogels, featuring high biocompatibility, tunable physicochemical properties, controllable structures, and multiple functionalization possibilities, have been developed as most-frequently-used cell reservoirs. Aiming at treating diseases or injuries with high efficiency, a series of porous and responsive hydrogels have been fabricated for the encapsulation of therapeutic cells. These cell-laden hydrogels have been applied in a broad range of pre-clinical researches of which results have demonstrated hopeful prospects in cell therapy. In this review, we highlight the recent progress of porous and responsive hydrogels used for cell encapsulation towards cell therapy. The hydrogels used for cell therapy are firstly classified. The porosity fabrication strategies of hydrogels are summarized and discussed. The responsive functionalities of hydrogels are surveyed, focusing on temperature-sensitivity, photo-sensitivity, pH-responsivity and biomolecule-sensitivity. Moreover, preclinical researches of hydrogels towards cell therapy, including the treatment of several diseases, such as diabetes mellitus, cancer, neuro disorders, cardiac diseases and bone injuries are discussed.
KW - Cell encapsulation
KW - Cell therapy
KW - Hydrogels
KW - Porosity
KW - Stimuli-responsivity
UR - http://www.scopus.com/inward/record.url?scp=85056224296&partnerID=8YFLogxK
U2 - 10.1016/j.cocis.2018.10.010
DO - 10.1016/j.cocis.2018.10.010
M3 - Review article
AN - SCOPUS:85056224296
VL - 38
SP - 135
EP - 157
JO - Current Opinion in Colloid and Interface Science
JF - Current Opinion in Colloid and Interface Science
SN - 1359-0294
ER -