Pharmacomodulation of torasemide led to original diuretic, neuroproptective anticonvulsant and antithrombotic drugs

B. Masereel, J. M. Dogné, J. Damas, A. Nuhrich, M. Varache-Lembège, J. Fontaine, L. Pochet, F. Somers, P. De Tullio, B. Pirotte, J. Delarge

Research output: Contribution to journalShort surveypeer-review

Abstract

Pharmacomodulation of torasemide, a diuretic sulfonylurea, led to the discovery of two novel diuretics, a sulfonylthiourea (BM 20) and a sulfonylcyanoguanidine (BM 106). BM 27, a lipophilic sulfonylurea, exhibited neuroprotective properties associated to an anticonvulsant activity. As BM 27, two lipophilic sulfonylthioureas (BM 11 and BM 34) revealed an anticonvulsant profile similar to that of phenytoin. Finally the synthesis of torasemide derivatives led to the development of a sulfonylcyanoguanidine (BM 144) with a thromboxane A2 antagonist potency.

Original languageEnglish
Pages (from-to)157-158
Number of pages2
JournalJournal de Pharmacie de Belgique
Volume52
Issue number4
Publication statusPublished - 1 Jul 1997

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