Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.

Christophe DEBACQ, N. Gillet, B. Asquith, M.-T. Sanchez-Alcaraz, A.-F. Florins, Mathieu Boxus, I. Schwartz-Cornil, M. Bonneau, Grégori Jean, P. Kerkhofs, A. Thewis, R Kettmann, L. Willems, Jack B. Hay

Research output: Contribution to journalArticlepeer-review

Abstract

[en] The size of a lymphocyte population is primarily determined by a dynamic equilibrium between cell proliferation and death. Hence, lymphocyte recirculation between the peripheral blood and lymphoid tissues is a key determinant in the maintenance of cell homeostasis. Insights into these mechanisms can be gathered from large-animal models, where lymphatic cannulation from individual lymph nodes is possible. In this study, we assessed in vivo lymphocyte trafficking in bovine leukemia virus (BLV)-infected sheep. With a carboxyfluorescein diacetate succinimidyl ester labeling technique, we demonstrate that the dynamics of lymphocyte recirculation is unaltered but that accelerated proliferation in the lymphoid tissues is compensated for by increased death in the peripheral blood cell population. Lymphocyte homeostasis is thus maintained by biphasic kinetics in two distinct tissues, emphasizing a very dynamic process during BLV infection.
Original languageEnglish
Pages (from-to)9710-9719
Number of pages10
JournalJournal of Virology
Volume80
Issue number19
DOIs
Publication statusPublished - 2006
Externally publishedYes

Keywords

  • Sciences du vivant => Agriculture agronomie
  • Sciences du vivant => Biochimie, biophysique biologie moléculaire
  • Sciences de la santé humaine => Oncologie
  • B-cell homeostasis
  • Bovine Leukemia Virus
  • Peripheral blood circulation
  • Virology
  • Microbiology
  • Sheep
  • Lymphoid tissues
  • Infection
  • Deltaretrovirus
  • Homéostasie des cellules B
  • Virus de la leucémie bovine
  • Circulation sanguine périphérique
  • Tissus lymphoïdes
  • Delta rétrovirus
  • Virologie
  • Microbiologie
  • Mouton

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