Partial alkyne reduction in flow: Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4

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Abstract

Combretastatin A-4 (1) is a natural product isolated from the South African bushwillow tree Combretum caffrum and endowed with a powerful inhibitory activity on microtubule formation as well as a related antiangiogenic activity.1-3 As such, 1 has a strong potential in the anticancer therapy. A lot of effort has been done on the development of new derivatives of this compound, in order to improve the properties such as solubility and stability and to understand the structure-activity relationships around this series.4-7 Our group has recently turned its attention to developing a synthetic procedure for combretastatin A-4 performed entirely in flow, which should enable continuous production of this useful compound and its derivatives in significant quantities. The full results of this work will be presented in due course.

A crucial step in this synthetic strategy is a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond present in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products more stable than Z-stilbenes.8 We therefore set out to explore the applicability of this technique within our synthetic procedure and also decided to expand it to a wider range of structurally various alkynes. The experimental conditions have been varied according to the general scheme below and the - rather promising - results are shown in the poster.
Original languageEnglish
Publication statusPublished - 16 Oct 2013
EventFROST4 - 4th Conference on Frontiers in Organic Synthesis Technology - Budapest, Hungary
Duration: 16 Oct 201318 Oct 2013

Conference

ConferenceFROST4 - 4th Conference on Frontiers in Organic Synthesis Technology
CountryHungary
CityBudapest
Period16/10/1318/10/13

Keywords

  • Lindlar reduction, combretastatin A-4

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    • 3 Participation in conference
    • 2 Participation to a Symposium, a study Day

    BOSS XIV - 14th Belgian Organic Synthesis Symposium

    Eduard Dolusic (Poster)

    13 Jul 201418 Jul 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Balticum Organicum Syntheticum 2014

    Eduard Dolusic (Poster)

    6 Jul 20149 Jul 2014

    Activity: Participating in or organising an event typesParticipation in conference

    Microfluidics: Fundamentals and Applications - BePCIS symposium

    Eduard Dolusic (Participant)

    8 May 2014

    Activity: Participating in or organising an event typesParticipation to a Symposium, a study Day

    Cite this

    De Backer, L., Dolušić, E., Collin, S., & Lanners, S. (2013). Partial alkyne reduction in flow: Adaptation of the lindlar protocol prompted by a flow synthesis of combretastatin A-4. Poster session presented at FROST4 - 4th Conference on Frontiers in Organic Synthesis Technology, Budapest, Hungary. http://www.frostconferences.com/