Projects per year
Presented in this poster is a crucial step in this synthetic strategy - a selective semi-reduction of the triple bond of an alkyne precursor to the Z-double bond in the final product. The Lindlar-type hydrogenation in flow has been described only scarcely and for products typically more stable than Z-stilbenes. We therefore set out to explore this technique and decided to expand it to a wider range of structurally various alkynes.
 C. M. Lin, S. B. Singh, P. S. Chu, R. O. Dempcy, J. M. Schmidt, G. R. Pettit, E. Hamel, Mol. Pharmacol. 1988, 34, 200.
 D. J. Kerr, E. Hamel, M. K. Jung, B. L. Flynn, Bioorg. Med Chem. 2007, 15, 3290.
 M. Marrelli, F. Conforti, G. A. Statti, X. Cachet, S. Michel, F. Tillequin, F. Menichini, Curr. Med. Chem. 2011, 18, 3035.
 Y. S. Shan, J. Zhang, Z. Liu, M. Wang, Y. Dong, Curr. Med. Chem. 2011,18, 523.
 C. Spatafora, C. Tringali, Anticancer Agents Med. Chem. 2012, 12, 902.
 R. Mikstacka, T. Stefanski, J. Rozanski, Cell. Mol. Biol. Lett. 2013, 18, 368.
 S. Chandrasekhar, B.V.D. Vijaykumar, B. Mahesh Chandra, Ch. Raji Reddy, P. Naresh, Tet. Lett. 2011, 52, 3865.
|Number of pages||1|
|Publication status||Published - 5 Dec 2013|
|Event||17th Sigma-Aldrich Organic Synthesis Meeting - Duinse Polders, Blankenberge, Belgium|
Duration: 5 Dec 2013 → 6 Dec 2013
|Symposium||17th Sigma-Aldrich Organic Synthesis Meeting|
|Period||5/12/13 → 6/12/13|
Activities per year
Eduard Dolusic (Poster)
Activity: Participating in or organising an event types › Participation in conference
Eduard Dolusic (Participant)
Activity: Participating in or organising an event types › Participation to a Symposium, a study Day