Abstract
Cyclooxygenase-2 and release of prostaglandin E2 are up-regulated in replicative senescence of dermal and prostate fibroblasts and in H2O2-induced premature senescence of IMR-90 lung fibroblasts expressing the catalytic subunit of telomerase. Inhibition of cyclooxygenase-2 activity by specific chemical inhibitor or siRNA attenuates the H2O2-induced increase of senescence associated β-galactosidase positive cells and attenuates growth arrest. In this work, p38MAPK activation and increased DNA binding activities of ATF-2 and p53 are shown to mediate cyclooxygenase-2 overexpression in premature senescence.
Original language | English |
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Pages (from-to) | 291-298 |
Number of pages | 8 |
Journal | Biogerontology |
Volume | 10 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 2009 |
Keywords
- ATF-2
- COX-2
- Hydrogen peroxide
- p38
- p53
- Senescence