P38
                    MAPK in the senescence of human and murine fibroblasts

Florence Debacq-Chainiaux; Emmanuelle Boilan; Jérémie Dedessus Le Moutier; Geoffroy Weemaels; Olivier Toussaint

doi:10.1007/978-1-4419-7002-2_10

P38 ^MAPK in the senescence of human and murine fibroblasts

Florence Debacq-Chainiaux, Emmanuelle Boilan, Jérémie Dedessus Le Moutier, Geoffroy Weemaels, Olivier Toussaint

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Abstract

Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Pages	126-137
Number of pages	12
Volume	694
DOIs	https://doi.org/10.1007/978-1-4419-7002-2_10
Publication status	Published - 1 Dec 2010

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	694
ISSN (Print)	00652598

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abstract = "Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.",

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P38 ^MAPK in the senescence of human and murine fibroblasts. / Debacq-Chainiaux, Florence; Boilan, Emmanuelle; Le Moutier, Jérémie Dedessus et al.
Advances in Experimental Medicine and Biology. Vol. 694 2010. p. 126-137 (Advances in Experimental Medicine and Biology; Vol. 694).

Research output: Contribution in Book/Catalog/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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T1 - P38 MAPK in the senescence of human and murine fibroblasts

AU - Debacq-Chainiaux, Florence

AU - Boilan, Emmanuelle

AU - Le Moutier, Jérémie Dedessus

AU - Weemaels, Geoffroy

AU - Toussaint, Olivier

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.

AB - Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.

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SN - 9781441970015

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T3 - Advances in Experimental Medicine and Biology

SP - 126

EP - 137

BT - Advances in Experimental Medicine and Biology

ER -

P38 ^MAPK in the senescence of human and murine fibroblasts

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