P38 MAPK in the senescence of human and murine fibroblasts

Florence Debacq-Chainiaux, Emmanuelle Boilan, Jérémie Dedessus Le Moutier, Geoffroy Weemaels, Olivier Toussaint

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)peer-review

6 Downloads (Pure)


Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages12
Publication statusPublished - 1 Dec 2010

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)00652598


Dive into the research topics of 'P38 MAPK in the senescence of human and murine fibroblasts'. Together they form a unique fingerprint.

Cite this