P38 MAPK in the senescence of human and murine fibroblasts

Florence Debacq-Chainiaux, Emmanuelle Boilan, Jérémie Dedessus Le Moutier, Geoffroy Weemaels, Olivier Toussaint

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)

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Abstract

Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages126-137
Number of pages12
Volume694
DOIs
Publication statusPublished - 1 Dec 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume694
ISSN (Print)00652598

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