Original reactions of α,α-dithio aryl alkanes with butyllithiums

A. Krief, B. Kenda, P. Barbeaux

Research output: Contribution to journalArticlepeer-review


Thioacetals derived from aromatic ketones react with butyllithiums already at -78°C and produce via a reductive process the corresponding α-thiobenzyllithiums in high yields. The same reaction also takes place selectively, under suitable conditions, with the thioacetals derived from benzaldehyde on which a competing metallation reaction is also possible. These observations clearly show that the thioacetal functionality is not a suitable protecting group against alkyllithiums for aromatic carbonyl compounds.
Original languageEnglish
Pages (from-to)2509-2512
Number of pages4
JournalTetrahedron Letters
Issue number22
Publication statusPublished - 1 Jan 1991


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