TY - JOUR
T1 - Optic neuritis associated or not with TNF antagonists in patients with inflammatory bowel disease
AU - for the ECCO CONFER investigators
AU - Alexandre, Benjamin
AU - Vandermeeren, Yves
AU - Dewit, Olivier
AU - Moreels, Tom
AU - de Boer, Nanne
AU - Dhar, Anjan
AU - Ziady, Chris
AU - Shitrit, Ariella Bar Gil
AU - Steinwurz, Flavio
AU - Jojic, Njegica
AU - Costantino, Giuseppe
AU - Bihin, Benoit
AU - Rahier, Jean François
AU - Katsanos, Konstantinos H.
N1 - Publisher Copyright:
© 2016 European Crohn's and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved.
PY - 2016/1/12
Y1 - 2016/1/12
N2 - Background and Aims: Acute optic neuritis [ON] is an inflammatory condition affecting the optic nerve. Clinicians should suspect optic neuritis in cases of painful and rapidly progressive loss of central visual field. This condition may be associated with a multitude of diseases, and mostly with multiple sclerosis [MS] where it may present as an initial symptom. The literature reports that optic neuritis and MS occur in patients with inflammatory bowel disease [IBD] before and after the era of anti-tumour necrosis factor-α [TNFα] drugs. At the present moment, there is little consensus for managing this complication, currently treated with corticosteroids and discontinuation of the causative agents. Methods: We collected cases through a retrospective multicentre European Crohn's and Colitis Organisation CONFER [COllaborative Network For Exceptionally Rare case reports] project. We also performed a comprehensive retrospective search of the available literature on this topic. Results: We report herein 12 new cases of ON, including 10 under anti-TNF therapy, collected through the CONFER project. We also compare characteristics of ON associated or not with anti-TNFα agents. Conclusions: The exceptional and current observation of distant family history of MS in 17% of our patients who developed ON, despite the small number and the lack of a control arm, might be an important signal that should be taken into account in our therapeutic strategies in the future.
AB - Background and Aims: Acute optic neuritis [ON] is an inflammatory condition affecting the optic nerve. Clinicians should suspect optic neuritis in cases of painful and rapidly progressive loss of central visual field. This condition may be associated with a multitude of diseases, and mostly with multiple sclerosis [MS] where it may present as an initial symptom. The literature reports that optic neuritis and MS occur in patients with inflammatory bowel disease [IBD] before and after the era of anti-tumour necrosis factor-α [TNFα] drugs. At the present moment, there is little consensus for managing this complication, currently treated with corticosteroids and discontinuation of the causative agents. Methods: We collected cases through a retrospective multicentre European Crohn's and Colitis Organisation CONFER [COllaborative Network For Exceptionally Rare case reports] project. We also performed a comprehensive retrospective search of the available literature on this topic. Results: We report herein 12 new cases of ON, including 10 under anti-TNF therapy, collected through the CONFER project. We also compare characteristics of ON associated or not with anti-TNFα agents. Conclusions: The exceptional and current observation of distant family history of MS in 17% of our patients who developed ON, despite the small number and the lack of a control arm, might be an important signal that should be taken into account in our therapeutic strategies in the future.
KW - Anti-TNF
KW - Inflammatory bowel disease
KW - Multiple sclerosis
KW - Optic neuritis
KW - Papillitis
KW - Retrobulbar neuritis
UR - http://www.scopus.com/inward/record.url?scp=84982204045&partnerID=8YFLogxK
U2 - 10.1093/ecco-jcc/jjw003
DO - 10.1093/ecco-jcc/jjw003
M3 - Article
C2 - 26759360
SN - 1873-9946
VL - 10
SP - 541
EP - 548
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - 5
ER -