Novel pharmaceutical compositions through co-crystallization of racetams and Li salts

J. Wouters, F. Grepioni, D. Braga, R.M. Kaminski, S. Rome, L. Aerts, L. Quéré

Research output: Contribution to journalArticle

Abstract

Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.
Original languageEnglish
Pages (from-to)8898-8902
Number of pages5
JournalCrystEngComm
Volume15
Issue number44
DOIs
Publication statusPublished - 28 Nov 2013

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Crystallization
Lithium
Drug products
Salts
lithium
crystallization
salts
Crystallography
grinding
Chemical analysis
Pharmaceutical Preparations
crystallography
drugs
Thermodynamic properties
thermodynamic properties
Association reactions
Single crystals
Crystals
single crystals
products

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Wouters, J., Grepioni, F., Braga, D., Kaminski, R. M., Rome, S., Aerts, L., & Quéré, L. (2013). Novel pharmaceutical compositions through co-crystallization of racetams and Li salts. CrystEngComm, 15(44), 8898-8902. https://doi.org/10.1039/c3ce41539b
Wouters, J. ; Grepioni, F. ; Braga, D. ; Kaminski, R.M. ; Rome, S. ; Aerts, L. ; Quéré, L. / Novel pharmaceutical compositions through co-crystallization of racetams and Li salts. In: CrystEngComm. 2013 ; Vol. 15, No. 44. pp. 8898-8902.
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Wouters, J, Grepioni, F, Braga, D, Kaminski, RM, Rome, S, Aerts, L & Quéré, L 2013, 'Novel pharmaceutical compositions through co-crystallization of racetams and Li salts', CrystEngComm, vol. 15, no. 44, pp. 8898-8902. https://doi.org/10.1039/c3ce41539b

Novel pharmaceutical compositions through co-crystallization of racetams and Li salts. / Wouters, J.; Grepioni, F.; Braga, D.; Kaminski, R.M.; Rome, S.; Aerts, L.; Quéré, L.

In: CrystEngComm, Vol. 15, No. 44, 28.11.2013, p. 8898-8902.

Research output: Contribution to journalArticle

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