Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.
Wouters, J., Grepioni, F., Braga, D., Kaminski, R. M., Rome, S., Aerts, L., & Quéré, L. (2013). Novel pharmaceutical compositions through co-crystallization of racetams and Li salts. CrystEngComm, 15(44), 8898-8902. https://doi.org/10.1039/c3ce41539b