Novel pharmaceutical compositions through co-crystallization of racetams and Li salts

J. Wouters, F. Grepioni, D. Braga, R.M. Kaminski, S. Rome, L. Aerts, L. Quéré

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Abstract

Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.
Original languageEnglish
Pages (from-to)8898-8902
Number of pages5
JournalCrystEngComm
Volume15
Issue number44
DOIs
Publication statusPublished - 28 Nov 2013

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Wouters, J., Grepioni, F., Braga, D., Kaminski, R. M., Rome, S., Aerts, L., & Quéré, L. (2013). Novel pharmaceutical compositions through co-crystallization of racetams and Li salts. CrystEngComm, 15(44), 8898-8902. https://doi.org/10.1039/c3ce41539b